The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pan-carcinoma membrane antigen. [In-111]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.
第一作者单位：[*1]UNIV GRONINGEN,DEPT CLIN IMMUNOL,OOSTERSINGEL 59,9713 EZ GRONINGEN,NETHERLANDS
通讯作者：
通讯机构：[*1]UNIV GRONINGEN,DEPT CLIN IMMUNOL,OOSTERSINGEL 59,9713 EZ GRONINGEN,NETHERLANDS
推荐引用方式(GB/T 7714)：
DEJONGE MWA,KOSTERINK JGW,BIN YY,et al.RADIOIMMUNODETECTION OF HUMAN SMALL-CELL LUNG-CARCINOMA XENOGRAFTS IN THE NUDE RAT USING IN-111 LABELED MONOCLONAL-ANTIBODY MOC-31[J].EUROPEAN JOURNAL of CANCER.1993,29A(13):1885-1890.doi:10.1016/0959-8049(93)90543-O.
APA：
DEJONGE, MWA,KOSTERINK, JGW,BIN, YY,BULTE, JWM,KENGEN, RAM...&DELEIJ, L.(1993).RADIOIMMUNODETECTION OF HUMAN SMALL-CELL LUNG-CARCINOMA XENOGRAFTS IN THE NUDE RAT USING IN-111 LABELED MONOCLONAL-ANTIBODY MOC-31.EUROPEAN JOURNAL of CANCER,29A,(13)
MLA：
DEJONGE, MWA,et al."RADIOIMMUNODETECTION OF HUMAN SMALL-CELL LUNG-CARCINOMA XENOGRAFTS IN THE NUDE RAT USING IN-111 LABELED MONOCLONAL-ANTIBODY MOC-31".EUROPEAN JOURNAL of CANCER 29A..13(1993):1885-1890
医学