单位：[1]CITY HOPE NATL MED CTR,DEPT RADIOL RES,DE VORKIN 108,1500 E DUARTE RD,DUARTE,CA 91010[2]CHINA JAPAN FRIENDSHIP HOSP,DEPT THORAC SURG,BEIJING,PEOPLES R CHINA
The expression of transforming growth factor-alpha (TGFalpha) was assessed by immunohistochemical staining in 52 human lung tumor samples. All of the 8 small cell lung cancers were negative whereas all of the 18 adenocarcinomas and 23 of the 26 squamous cell carcinomas showed positive immunoreaction to TGFalpha. Distribution of TGFalpha stainings in the squamous cell carcinomas was weaker and more heterogeneous as compared to the adenocarcinomas. Ultrastructural localization of TGFalpha in the squamous cell lung carcinomas by indirect immunogold staining revealed that TGFalpha is present in the cytoplasm as well as the cell membrane but not in the nucleus. This suggests that the lung cancer cells are not only the producer of TGFalpha, but also the target cells of the TGFalpha action. The expression of TGFalpha in lung tumors may be useful diagnostically in differentiating small cell lung cancer from non-small cell lung cancer and may also be important in the study of the biological properties of primary lung cancers.
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外文
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推荐引用方式(GB/T 7714)：
LIU M,XIN YL,CHEN FM.IMMUNOHISTOCHEMICAL STUDY OF TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN LUNG CANCERS[J].TUMOR BIOLOGY.1992,13(5-6):294-298.doi:10.1159/000217778.
APA：
LIU, M,XIN, YL&CHEN, FM.(1992).IMMUNOHISTOCHEMICAL STUDY OF TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN LUNG CANCERS.TUMOR BIOLOGY,13,(5-6)
MLA：
LIU, M,et al."IMMUNOHISTOCHEMICAL STUDY OF TRANSFORMING GROWTH FACTOR-ALPHA IN HUMAN LUNG CANCERS".TUMOR BIOLOGY 13..5-6(1992):294-298
