单位：[1]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University,National Clinical ResearchCenter for Digestive Diseases,Beijing Digestive Disease Center,Beijing Key Laboratory for Precancerous Lesionof Digestive Diseases, Beijing, 100050, China临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院[2]Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital,Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing, 100050, China医技科室北京市临床医学研究所国家消化中心（方法学平台）首都医科大学附属北京友谊医院[3]Department of Pathology, Beijing Friendship Hospital, Capital Medical University,National Clinical ResearchCenter for Digestive Diseases, Beijing, 100050, China医技科室病理科病理科首都医科大学附属北京友谊医院[4]Gastroenterology Research Unit, Department of Cellular andMolecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK
Gastric hyperplastic polyps (GHPs) have a potential risk of neoplastic transformation, but the responsible mechanisms have not yet been established. We conducted a study involving 55 patients (33 female) who had undergone endoscopic or surgical resection of GHPs. We compared 16 patients who had GHPs showing neoplastic transformation with 39 patients who had non-neoplastic GHPs. We analyzed differences in serology, gastroscopic manifestations and pathology between the two groups in order to establish risk factors that may be associated with neoplastic transformation. The mean age of the cohort was 61.73 +/- 9.024 years. The prevalence of positive serum gastric parietal cell antibody (PCA) was 61.8%. 30 of the GHPs with neoplastic formation had a "strawberry-like" appearance with erosions of polyps (P = 0.000). A history of anaemia was a risk factor for GHPs which demonstrated neoplastic transformation (odds ratio [OR], 3.729; 95% confidence interval [CI], 1.099-12.649; P = 0.035). Although the differences were not significant, our data showed higher prevalences of positive serum PCA (P = 0.057), hypergastrinemia (P = 0.062) and female gender (P = 0.146) in the GHP patients who had neoplastic transformation. Multiple polyps in the corpus (P = 0.024) occurred more frequently in serum PCA positive patients. Hypergastrinemia occurred more frequently in Helicobacter pylori negative patients and of these 20/22 patients had a positive PCA (P = 0.007). GHPs are associated with autoimmune metaplastic atrophic gastritis (AMAG). AMAG is probably one of the risk factors for GHPs to undergo neoplastic transformation.
第一作者单位：[1]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University,National Clinical ResearchCenter for Digestive Diseases,Beijing Digestive Disease Center,Beijing Key Laboratory for Precancerous Lesionof Digestive Diseases, Beijing, 100050, China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu H,Zhang Q,Chen G,et al.Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients[J].SCIENTIFIC REPORTS.2020,10(1):doi:10.1038/s41598-020-58900-z.
APA：
Hu, H,Zhang, Q,Chen, G,Pritchard, D.M&Zhang, S.(2020).Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients.SCIENTIFIC REPORTS,10,(1)
MLA：
Hu, H,et al."Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients".SCIENTIFIC REPORTS 10..1(2020)
