Triple-negative breast cancer (TNBC) comprises about 10-20% of all diagnosed breast cancers. Increasing evidence shows that the omega-3 polyunsaturated fatty acids (omega-3PUFAs), docosahexaenoic acid and eicosapentaenoic acid, can influence the development, progression, and prognosis of TNBC In Vivo and In Vitro; however, clinical evidence supporting the effect of omega-3PUFAs on TNBC is lacking. Research has demonstrated that omega-3PUFAs can induce apoptosis in breast cancer cells by inhibiting the PI3K/AKT signal transduction pathway, and that omega-3PUFAs can improve the effectiveness of chemotherapy drugs. Using omega-3PUFA supplementation in addition to pharmacotherapy in the treatment of breast cancer may result in enhanced anti-tumor effects that will be particularly applicable to difficult to treat phenotypes such as TNBC. The aim of the current review was to summarize the evidence-base supporting the antitumor effects of omega-3 PUFAs in TNBC.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7172061]; China Population Publicity and Education Center Research and Promotion Project [2017-A001]; Beijing Municipal Administration of Hospitals'Youth Program [QML20170102]
第一作者单位：[1]Department of Cancer Center, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China
通讯作者：
通讯机构：[1]Department of Cancer Center, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China[*1]Department of Cancer Center, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xicheng, Beijing 100050, P.R. China
推荐引用方式(GB/T 7714)：
Ma Y,Wang J,Li Q,et al.The Effect of Omega-3 Polyunsaturated Fatty Acid Supplementations on anti-Tumor Drugs in Triple Negative Breast Cancer[J].NUTRITION and CANCER-AN INTERNATIONAL JOURNAL.2021,73(2):196-205.doi:10.1080/01635581.2020.1743873.
APA：
Ma, Y,Wang, J,Li, Q&Cao, B.(2021).The Effect of Omega-3 Polyunsaturated Fatty Acid Supplementations on anti-Tumor Drugs in Triple Negative Breast Cancer.NUTRITION and CANCER-AN INTERNATIONAL JOURNAL,73,(2)
MLA：
Ma, Y,et al."The Effect of Omega-3 Polyunsaturated Fatty Acid Supplementations on anti-Tumor Drugs in Triple Negative Breast Cancer".NUTRITION and CANCER-AN INTERNATIONAL JOURNAL 73..2(2021):196-205
