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Chemical constituents from ripe fruit of Cornus officinalis

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收录情况： ◇ 统计源期刊 ◇ 北大核心 ◇ CSCD-C

作者：

单位： [1]School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China. [2]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China. [3]Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China. [4]Pharmaceutical Institute, Henan University, Kaifeng 475004, China. [5]Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. [6]School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China. [7]Beijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Beijing 100029, China.

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摘要：

To investigate the chemical compounds from the fruit of Cornus officinalis, six compounds were isolated and determined by extensive spectroscopic analysis as 6'-O-acetyl-7α-O-ethyl morroniside (1), (-)-isolariciresinol 3α-O-β-D-glucopyranoside(2), apigenin (3), cirsiumaldehyde(4), p-coumaric acid (5), caffeic acid (6). Compound 1 was a new iridoid glucoside,and compounds 2-4 were obtained from the Cornus genus for the first time. Compounds 2-6 were evaluated for the viability of PC12 cells when exposed in conditions of oxygen and glucose deprivation. The MTT results showed that compound 4 increased cell viability moderately in OGD/R treated PC12 cells at the concentration of 1.0 μmol•L⁻¹.Copyright© by the Chinese Pharmaceutical Association.

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第一作者单位： [1]School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China. [2]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China.

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