单位：[1]Department of Dermatology, Beijing Friendship Hospital Affiliated, Capital University of Medical Sciences, Beijing 100050, China.临床科室皮肤性病科皮肤性病科首都医科大学附属北京友谊医院
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摘要：
To investigate the effects of intense pulse light (IPL) on the mRNA expression of type I procollagen in human fibroblasts.Four healthy female subjects aged 19 - 41, underwent IPL on the back skin 3 times with an interval of 2 weeks. Before the IPL and after 1, 2, and 3 times of treatment samples of back skin were obtained to undergo real time quantitative PCR to detect the mRNA expression of type I procollagen.The mRNA expression level of type I procollagen after one time of IPL treatment was [(4.7 +/- 1.0) x 10(-4)], not significantly different from that before treatment [(2.1 +/- 0.7) x 10(-4), P = 0.100]. The mRNA expression levels of type I procollagen after treatment for 2 times and 3 -time were (7.9 +/- 1.7) x 10(-4) and (11.1 +/- 2.4) x 10(-4) respectively, both significantly higher than that before treatment (both P < 0.05).Promoting the mRNA transcription of type I procollagen in dermal fibroblasts, IPL therapy is effective in dermal remodeling and wrinkle removing.
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中文
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第一作者：
第一作者单位：[1]Department of Dermatology, Beijing Friendship Hospital Affiliated, Capital University of Medical Sciences, Beijing 100050, China.
推荐引用方式(GB/T 7714)：
Mei Xue-Ling,Zhao Jun-Ying,Cui Yan.Effects of intense pulse light on the mRNA expression of type I procollagen in human fibroblasts[J].Zhonghua Yi Xue Za Zhi.2008,88(6):398-9.
