To investigate the problems of diagnosis and treatment in patients with benign tumor of duodenum.Clinico pathological data of 8 patients with benign tumors of duodenum treated surgically in our department from 1989 to 2000 were analyzed retrospectively.Of the 8 patients, 3 had a Brunner's grand adenoma, 2 leiomyoma, 2 mesenchymoma, and 1 lipoma. In general, the patients were asymptomatic and the lesions were discovered incidentally. Gastrointestinal bleeding might be the main symptom even if it was nonspecific. Bleeding might be melena or hematemesis and the patients might develop signs of anemia. Upper gastrointestinal tract examination and gastroduodenoscopy was performed before operation in 7 patients. The tumor was removed through longitudinal incision during duodenotomy.Gastrointestinal bleeding is common in patients with benign tumor of duodenum. The upper gastrointestinal tract examination and gastroduodenoscopy are major methods for diagnosis. The best treatment of choice is local resection.