Background and Objective: Recently, deep convolutional neural network has significantly improved image classification and image segmentation. If coronary artery disease (CAD) can be diagnosed through machine learning and deep learning, it will significantly reduce the burdens of the doctors and accelerate the critical patient diagnoses. The purpose of the study is to assess the practicability of utilizing deep learning approaches to process coronary computed tomographic angiography (CCTA) imaging (termed CCTA-artificial intelligence, CCTA-AI) in coronary artery stenosis. Materials and Methods: A CCTA reconstruction pipeline was built by utilizing deep learning and transfer learning approaches to generate auto-reconstructed CCTA images based on a series of two-dimensional (2D) CT images. 150 patients who underwent successively CCTA and digital subtraction angiography (DSA) from June 2017 to December 2017 were retrospectively analyzed. The dataset was divided into two parts comprising training dataset and testing dataset. The training dataset included the CCTA images of 100 patients which are trained using convolutional neural networks (CNN) in order to further identify various plaque classifications and coronary stenosis. The other 50 CAD patients acted as testing dataset that is evaluated by comparing the auto-reconstructed CCTA images with traditional CCTA images on the condition that DSA images are regarded as the reference method. Receiver operating characteristic (ROC) analysis was used for statistical analysis to compare CCTA-AI with DSA and traditional CCTA in the aspect of detecting coronary stenosis and plaque features. Results: AI significantly reduces time for post-processing and diagnosis comparing to the traditional methods. In identifying various degrees of coronary stenosis, the diagnostic accuracy of CCTA-AI is better than traditional CCTA (AUCA1 = 0.870, AUCcciA = 0.781, P < 0.001). In identifying > 50% stenotic vessels, the accuracy, sensitivity, specificity, positive predictive value and negative predictive value of CCTA-AI and traditional method are 86% and 83%, 88% and 59%, 85% and 94%, 73% and 84%, 94% and 83%, respectively. In the aspect of identifying plaque classification, accuracy of CCTA-AI is moderate compared to traditional CCTA (AUC = 0.750, P < 0.001). Conclusion: The proposed CCTA-AI allows the generation of auto-reconstructed CCTA images from a series of 2D CT images. This approach is relatively accurate for detecting >= 50% stenosis and analyzing plaque features compared to traditional CCTA. 2020 Elsevier B.V. All rights reserved.