单位：[1]Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室麻醉科麻醉科首都医科大学附属北京友谊医院[2]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院
Transmembrane protein 166 (TMEM166) is a lysosomal/endoplasmic reticulum (ER)-associated protein found in different species where it functions as a regulator of programmed cell death through autophagy and apoptosis. It is expressed in a variety of normal tissues and organs, and it is involved in a wide variety of physiological and pathological processes, including cancers, infection, autoimmune diseases, and neurodegenerative diseases. Previous studies indicated that TMEM166 is associated with autophagosomal membrane development. TMEM166 can cause lysosomal membrane permeabilization (LMP) leading to the release of proteolytic enzymes, e.g., cathepsins, that may cause potential mitochondrial membrane damage, which triggers several autophagic and apoptotic events. A low level of TMEM166 expression is also found in tumors, while high level of TMEM166 is found in brain ischemia. In addition, loss of TMEM166 leads to impaired NSC self-renewal and differentiation along with a decrease in autophagy. These findings offer a comprehensive understanding of the pathways involved in the role of TMEM166 in programmed cell death and treatment of various diseases.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81870926, 81500996]
第一作者单位：[1]Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, eijing, China
推荐引用方式(GB/T 7714)：
Yanwei Yang,Lingxue Zhou,Fushan Xue,et al.Transmembrane Protein 166 and its Significance[J].PROTEIN and PEPTIDE LETTERS.2021,28(4):382-387.doi:10.2174/0929866527666201002150316.
APA：
Yanwei Yang,Lingxue Zhou,Fushan Xue,Lixin An,Mu Jin&Li Li.(2021).Transmembrane Protein 166 and its Significance.PROTEIN and PEPTIDE LETTERS,28,(4)
MLA：
Yanwei Yang,et al."Transmembrane Protein 166 and its Significance".PROTEIN and PEPTIDE LETTERS 28..4(2021):382-387
