Maternal supplementation with combined galactooligosaccharides and casein glycomacropeptides modulated microbial colonization and intestinal development of neonatal piglets
单位：[1]State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China[2]Department of Obstetrics and Gynaecology, China-Japan Friendship Hospital, Beijing 100029, China[3]National Engineering Centre of Dairy for Early Life Health, Beijing Sanyuan Foods Co. Ltd, Beijing 100163, China
This study aimed to investigate the maternal effects of the combination (GC) of galactooligosaccharides (GOS) and casein glycomacropeptides (CGMP) on their offspring. Twenty-two multiparous sows were divided into CON group (basal diet) and GC group (basal diet plus GC, 10 g/d with a ratio of 2: 1). Our results indicated that GC supplementation elevated the litter's characteristics, faecal Prevotella, Fusobacterium and unclassified_f_Prevotellaceae of sows. Maternal GC supplementation also enriched norank_f_Ruminococcaceae, Christensenellaceae_R-7_group, Ruminococcaceae_UCG-005 and Ruminococcaceae_UCG-010, elevated their piglets' body weight on day 21 and enhanced intestinal barrier functions by upregulating mRNA transcript levels of tight junctions and mucins. Positive correlations of the enriched microbes and intestinal barrier parameters were found by the spearman correlation analysis. Collectively, maternal GC intervention modulated the neonatal microbiota colonization, which potentially promoted the gut development and growth performance of the piglets. Our findings will provide an insight for future application of GC in maternal-foetal nutrition.
基金：
Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [S170001]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31630074, 31902170]; National Key Research and Development Program of China [2016YFD0500506, 2018YDF0501002]; Fundamental Research Funds for the Centre Universities [2019TC223]; China Agricultural Research System [CARS-35]; 111 ProjectMinistry of Education, China - 111 Project [B16044]; Jinxinnong Animal Science Developmental Foundation
第一作者单位：[1]State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wu Yujun,Zhang Xiangyu,Tao Shiyu,et al.Maternal supplementation with combined galactooligosaccharides and casein glycomacropeptides modulated microbial colonization and intestinal development of neonatal piglets[J].JOURNAL of FUNCTIONAL FOODS.2020,74:doi:10.1016/j.jff.2020.104170.
APA：
Wu, Yujun,Zhang, Xiangyu,Tao, Shiyu,Pi, Yu,Han, Dandan...&Wang, Junjun.(2020).Maternal supplementation with combined galactooligosaccharides and casein glycomacropeptides modulated microbial colonization and intestinal development of neonatal piglets.JOURNAL of FUNCTIONAL FOODS,74,
MLA：
Wu, Yujun,et al."Maternal supplementation with combined galactooligosaccharides and casein glycomacropeptides modulated microbial colonization and intestinal development of neonatal piglets".JOURNAL of FUNCTIONAL FOODS 74.(2020)
