单位：[1]Departments of Gynecology and Obstetrics, China–Japan Friendship Hospital[2]Department of Pathology, China–Japan Friendship Hospital, Beijing, China[3]Department of Gynecology and Obstetrics, Changping Hospital of Chinese and Western Medicine, Beijing, China[4]Department of Medicine and Molecular Science, Gunma University, Maebeshi, Japan[5]Department of Gynecology Oncology, University of Chicago, Chicago, IL, USA[6]Department of Gynecology and Obstetrics, China–Japan Friendship Hospital, Beijing, China
Ovarian cancer (OC) is the most aggressive gynecological cancer. Even with the advances in detection and therapeutics, it still remains clinically challenging and there is a pressing need to identify novel therapeutic strategies. In searching for rational molecular targets, we identified metadherin (MTDH), a multifunctional gene associated with several tumor types but previously unrecognized in OC. In this study, we found the MTDH is overexpressed in OC tissues. Through in vitro assays with overexpression cells, we characterized the role of MTDH. We confirmed MTDH stable overexpression significantly increased the expression of TNF-alpha, IL-6, IL-8, IL-10, and IL-1 beta. Interestingly, NF-kappa-B (NF-kappa B) and MTDH were found in a feed-forward loop motif. Thus, our findings support the notion that the MTDH and NF-kappa B signaling network contributes to OC traits. MTDH represents a new OC-associated gene that can contribute to insights of OC biology and suggests other treatment strategies.
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区移植4 区细胞与组织工程
最新[2025]版：
大类|4 区医学
小类|3 区移植4 区细胞与组织工程4 区医学：研究与实验
JCR分区：
出版当年[2018]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2TRANSPLANTATIONQ3CELL & TISSUE ENGINEERING
最新[2023]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2TRANSPLANTATIONQ3CELL & TISSUE ENGINEERING
第一作者单位：[1]Departments of Gynecology and Obstetrics, China–Japan Friendship Hospital
通讯作者：
通讯机构：[6]Department of Gynecology and Obstetrics, China–Japan Friendship Hospital, Beijing, China[*1]Department of Gynecology and Obstetrics, China–Japan Friendship Hospital, No 2, East Yinghua Street, Chao Yang District, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Chunhong Rong,Yanfen Shi,Jun Huang,et al.The Effect of Metadherin on NF-kappa B Activation and Downstream Genes in Ovarian Cancer[J].CELL TRANSPLANTATION.2020,29:doi:10.1177/0963689720905506.
APA：
Chunhong Rong,Yanfen Shi,Jun Huang,Xinyue Wang,Risa Shimizu...&Jing Liang.(2020).The Effect of Metadherin on NF-kappa B Activation and Downstream Genes in Ovarian Cancer.CELL TRANSPLANTATION,29,
MLA：
Chunhong Rong,et al."The Effect of Metadherin on NF-kappa B Activation and Downstream Genes in Ovarian Cancer".CELL TRANSPLANTATION 29.(2020)
