单位：[1]State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, China[2]Beijing University of Chinese Medicine, Beijing, China[3]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China[4]National Clinical Research Center for Respiratory Diseases, Beijing, China[5]Department of Respiratory, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China[6]The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China
Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary inflammation, pulmonary fibrosis and lung dysfunction. Currently, the pathophysiological process of silicosis has not been well studied. Here, we defined the progression of silicosis as four stages by unsupervised clustering analysis: normal stage, inflammatory stage, progressive stage and fibrotic stage. Specifically, in normal stage, the lung function was normal, and no inflammation or fibrosis was detected in the lung tissue. Inflammatory stage showed a remarkable pulmonary inflammation but mild fibrosis and lung dysfunction. In progressive stage, significant lung dysfunction was observed, while pulmonary inflammation and fibrosis continued to deteriorate. Fibrotic stage revealed the most severe pulmonary fibrosis and lung dysfunction but no significant deterioration in inflammation. Since the common features were founded in both silicosis patients and rodents, we speculated that the pathophysiological processes of silicosis in patients might be similar to the rodents. Collectively, our new classification identified the process of silicosis, clarified the pathophysiological features of each stage, and provided some new insights for the progression of the disease.
基金：
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2018-I2M-1-001]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81622008, 91739107]; Thousand Young Talents Program of ChinaChinese Academy of Sciences
第一作者单位：[1]State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, China[3]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China[4]National Clinical Research Center for Respiratory Diseases, Beijing, China[*1]No.5 Dongdansantiao Street, Dongcheng District, Beijing, PR China.[*2]No.5 Dongdansantiao Street, Dongcheng District, Beijing, PR China
推荐引用方式(GB/T 7714)：
Cao Zhujie,Song Meiyue,Liu Ying,et al.A novel pathophysiological classification of silicosis models provides some new insights into the progression of the disease[J].ECOTOXICOLOGY and ENVIRONMENTAL SAFETY.2020,202:doi:10.1016/j.ecoenv.2020.110834.
APA：
Cao, Zhujie,Song, Meiyue,Liu, Ying,Pang, Junling,Li, Zhaoguo...&Wang, Chen.(2020).A novel pathophysiological classification of silicosis models provides some new insights into the progression of the disease.ECOTOXICOLOGY and ENVIRONMENTAL SAFETY,202,
MLA：
Cao, Zhujie,et al."A novel pathophysiological classification of silicosis models provides some new insights into the progression of the disease".ECOTOXICOLOGY and ENVIRONMENTAL SAFETY 202.(2020)
