单位：[a]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China临床科室耳鼻咽喉头颈外科耳鼻咽喉头颈外科首都医科大学附属北京友谊医院[b]Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China四川大学华西医院[c]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China首都医科大学附属天坛医院[d]Department of Emergency, Aviation General Hospital, Beijing 100012, China
The prognostic value of microvessel density (MVD) in head and neck squamous cell carcinoma (HNSCC) remains disputable. The purpose of this study was to comprehensively determine the prognostic value of MVD in HNSCC. Relevant literatures were identified using PubMed, Embase, and Cochrane Library. A meta-analysis was performed to clarify the prognostic role of MVD in HNSCC patients and different subgroups. A total of 14 eligible articles were included in this meta-analysis. The combined hazard ratio (HR) and 95% confidence interval (95% CI) for overall survival (OS) of 11 studies was 1.663 (1.236-2.237,P=0.001), and the pooled HR and 95% CI for progression-free survival (PFS) of 7 studies was 2.069 (1.281-3.343,P=0.003). Subgroup analyses were also performed on different issues, such as regional distribution of patients, age, tumor location, antibody, and treatment strategy. To conclude, high MVD is associated with worse OS and PFS in patients with HNSCC.
基金：
Research and Development Project of Scientific Research Instruments and Equipment of Chinese Academy of Sciences-major instruments project [YJKYYQ20180039]; Digestive Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals [XXZ0604]
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区生物工程与应用微生物3 区遗传学3 区病理学4 区医学：研究与实验
最新[2025]版：
无
JCR分区：
出版当年[2018]版：
Q2GENETICS & HEREDITYQ2PATHOLOGYQ2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[a]Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Dong Y,Ma G,Liu Y,et al.Prognostic Value of Microvessel Density in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis[J].DISEASE MARKERS.2020,2020:doi:10.1155/2020/8842795.
APA：
Dong, Y,Ma, G,Liu, Y,Lu, S&Liu, L.(2020).Prognostic Value of Microvessel Density in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis.DISEASE MARKERS,2020,
MLA：
Dong, Y,et al."Prognostic Value of Microvessel Density in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis".DISEASE MARKERS 2020.(2020)
