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A Prospective and Retrospective Clinical Controlled Observation of Chinese Herbal Decoction (SMLJ01) for Type 1 Gastric Neuroendocrine Tumors

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单位: [1]Beijing University of Chinese Medicine, Beijing, China [2]China-Japan Friendship Hospital, Beijing, China [3]Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China [4]The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China [5]Beijing Friendship Hospital, Capital Medical University,National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center,Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, China
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关键词: type 1 gastric neuroendocrine tumors recurrence Chinese herbs symptoms

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Introduction: Type 1 gastric neuroendocrine tumors (g-NETs) have a good prognosis but a high recurrence rate. Aim: To observe the clinical efficacy of the treatment of type 1 g-NETs with the Chinese herbal decoction SMLJ01. Materials and Methods: A prospective and retrospective, clinical, controlled observation was conducted in 4 Chinese centers from 2012 to 2019. Patients with type 1 g-NETs were nonrandomly divided into treatment and control groups after endoscopic treatment based on herbal treatment administered according to their wishes. The treatment group received oral SMLJ01, with follow-up every 6 to 12 months, while the control group received follow-up alone. Patient follow-up (via telephone) from 2012 to 2017 was mainly retrospective. All patients after 2017 were followed prospectively. The recurrence times and rates were compared after treatment for at least 6 months. Symptom improvements were evaluated in the treatment group. The follow-up ended on October 31, 2019. Results: During a median follow-up of 22 months (range: 2-86 months), the survival rate was 100%, and no metastases occurred. Twenty-one of the 82 treated patients (25.6%) had recurrence after a median of 22 months, and 22 of the 54 control patients (40.7%) had recurrence after a median of 8 months (P = .063). The Kaplan-Meier curve analysis showed that the patients in the treatment group had a significantly longer median recurrence-free survival (RFS) time than those in the control group (P = .001). The risk of recurrence in the treatment group was 0.38 relative to that in the control group (95% CI: 0.20-0.70). The symptom score of the patients after taking Chinese medicine was 19.5 (10.3, 28.0), which was significantly lower than before treatment (31.5 (19.3, 38.0)). The difference was statistically significant (P < .01). Conclusion: SMLJ01, with the effects of soothing the liver, strengthening the spleen, increasing acid and harmonizing the stomach, may help reduce the recurrence rate, relieve symptoms and prolong the recurrence time in patients with type 1 g-NETs and is worthy of evaluation with further randomized research with large sample sizes and longer follow-up periods.

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出版当年[2019]版:
大类 | 3 区 医学
小类 | 2 区 全科医学与补充医学 4 区 肿瘤学
最新[2025]版:
大类 | 4 区 医学
小类 | 3 区 全科医学与补充医学 4 区 肿瘤学
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出版当年[2018]版:
Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Q3 ONCOLOGY
最新[2023]版:
Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Q2 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均[2021-2025] 出版当年[2018版] 出版当年五年平均[2014-2018] 出版前一年[2017版] 出版后一年[2019版]

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第一作者单位: [1]Beijing University of Chinese Medicine, Beijing, China [2]China-Japan Friendship Hospital, Beijing, China
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通讯机构: [2]China-Japan Friendship Hospital, Beijing, China [*1]Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, 100029, China. [*2]Department of Pathology, China-Japan Friendship Hospital, Beijing, 100029, China
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