单位：[1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China[2]National Clinical Research Center for Respiratory Diseases, Beijing, China[3]Peking University Health Science Center, Beijing, China[4]Capital Medical University, Beijing, China[5]The Graduate School of Peking Union Medical College, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
Study Objectives: Blunted ventilatory responses to hypoxia and hypercapnia during resting conditions are common findings in patients with obesity hypoventilation syndrome (OHS). Exercise increases the work and oxygen cost of breathing and produces excessive carbon dioxide (CO2). The aim of this investigation was to study ventilatory responses to incremental exercise in patients with OHS. Methods: Sixty-eight obese adults with OHS(n = 15), eucapnic obstructive sleep apnea (n = 26), or simple obesity (n = 27) participated in an incremental exercise test on a cycle ergometer and an in-laboratory sleep study. Results: The peak oxygen uptake (peak VO2) and peak pulse oxygen was decreased in patients with OHS compared with patients with either obstructive sleep apnea or simple obesity. The ventilatory response to exertional metabolic demand (nadir VE/VCO2, Delta VE/Delta VCO2 slope, and VE/VCO2 at peak exercise) did not significantly differ among the 3 groups. Minute ventilation, tidal volume, respiratory frequency, tidal volume/respiratory frequency, and inspiratory time/total time ratio at a given work rate were comparable among the 3 groups. Among the whole cohort, apnea-hypopnea index was not independently associated with peak VO2, and no association was found between the Delta VE/Delta VCO2 slope and resting arterial partial pressure of CO2. Conclusions: The ventilatory response to incremental exercise is preserved in patients with OHS compared with patients with obstructive sleep apnea and simple obesity who were matched for age and body mass index. This result highlights the complexity of the respiratory control system during exercise for patients with OHS, which may be uncoupled with the ventilatory response during sleep and resting conditions.
基金：
Precision Medicine Project from the Ministry of Science and Technology of China [2016YFC0903602]
第一作者单位：[1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China[2]National Clinical Research Center for Respiratory Diseases, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China[2]National Clinical Research Center for Respiratory Diseases, Beijing, China[3]Peking University Health Science Center, Beijing, China[4]Capital Medical University, Beijing, China[5]The Graduate School of Peking Union Medical College, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China[*1]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Han Teng,Zhang Li,Yu Chun Yan,et al.Ventilatory response to exercise is preserved in patients with obesity hypoventilation syndrome[J].JOURNAL of CLINICAL SLEEP MEDICINE.2020,16(12):2089-2098.doi:10.5664/jcsm.8766.
APA：
Han Teng,Zhang Li,Yu Chun Yan,Li Yi Ming,Wang Yan&Zhang Xiao Lei.(2020).Ventilatory response to exercise is preserved in patients with obesity hypoventilation syndrome.JOURNAL of CLINICAL SLEEP MEDICINE,16,(12)
MLA：
Han Teng,et al."Ventilatory response to exercise is preserved in patients with obesity hypoventilation syndrome".JOURNAL of CLINICAL SLEEP MEDICINE 16..12(2020):2089-2098
