单位：[1]Department of Pulmonary and Critical CareMedicine, Laboratory of Clinical Microbiology andInfectious Diseases, Center for RespiratoryDiseases, National Clinical Research Center ofRespiratory Diseases, China-Japan FriendshipHospital, Beijing 100029, People’s Republic ofChina[2]Department of Laboratory Medicine,Henan Provincial People’s Hospital, Zhengzhou,People’s Republic of China[3]Department ofLaboratory Medicine, Wuhan Pu Ai Hospital ofHuazhong University of Science and Technology,Wuhan, People’s Republic of China[4]Departmentof Laboratory Medicine, Ningbo Medical CenterLihuili Hospital, Ningbo, People’s Republic ofChina[5]Department of Laboratory Medicine,Weifang No.2 People’s Hospital, Weifang, People’sRepublic of China[6]Clinical Center for PulmonaryInfections, Capital Medical University, Beijing,People’s Republic of China[7]Tsinghua University-Peking University, Joint Center for Life Sciences,Beijing, People’s Republic of China
Purpose: Pseudomonas aeruginosa bacteremia presents a severe challenge to hospitalized patients. However, to date, the risk factors for mortality among inpatients with P. aeruginosa bacteremia in China remain unclear. Patients and Methods: This retrospective multicenter study was performed to analyze 215 patients with culture-confirmed P. aeruginosa bacteremia in five healthcare centers in China during the years 2012-2019. Results: Of 215 patients with P. aeruginosa bacteremia, 61 (28.4%) died during the study period. Logistic multivariable analysis revealed that cardiovascular disease (OR=3.978, P=0.001), blood transfusion (OR=5.855, P<0.001) and carbapenem-resistant P. aeruginosa (CRPA) phenotype (OR=4.485, P=0.038) constituted the independent risk factors of mortality. Furthermore, both CRPA and multidrug-resistant P. aeruginosa (MDRPA) phenotypes were found to be significantly associated with 5-day mortality (Log-rank, P<0.05). Conclusion: This study revealed a high mortality rate amongst hospitalized patients with P. aeruginosa bacteremia, and those with cardiovascular diseases, CRPA and MDRPA phenotypes, should be highlighted and given appropriate management in China.
基金：
National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [81425001/H0104]; CAMS Innovation Fund for Medical Sciences [CIFMS 2018-I2M-1-003]; National Key Research and Development Program of China [2018YFC1200102]
第一作者单位：[1]Department of Pulmonary and Critical CareMedicine, Laboratory of Clinical Microbiology andInfectious Diseases, Center for RespiratoryDiseases, National Clinical Research Center ofRespiratory Diseases, China-Japan FriendshipHospital, Beijing 100029, People’s Republic ofChina
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical CareMedicine, Laboratory of Clinical Microbiology andInfectious Diseases, Center for RespiratoryDiseases, National Clinical Research Center ofRespiratory Diseases, China-Japan FriendshipHospital, Beijing 100029, People’s Republic ofChina[6]Clinical Center for PulmonaryInfections, Capital Medical University, Beijing,People’s Republic of China[7]Tsinghua University-Peking University, Joint Center for Life Sciences,Beijing, People’s Republic of China[*1]Department of Pulmonary and Critical Care Medicine, Laboratory of Clinical Microbiology and Infectious Diseases, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Chaoyang District, Beijing 100029, People’s Republic of China
推荐引用方式(GB/T 7714)：
Zhang Yulin,Li Yi,Zeng Ji,et al.Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality[J].INFECTION and DRUG RESISTANCE.2020,13:4115-4123.doi:10.2147/IDR.S268744.
APA：
Zhang, Yulin,Li, Yi,Zeng, Ji,Chang, Yanzi,Han, Shouhua...&Cao, Bin.(2020).Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality.INFECTION and DRUG RESISTANCE,13,
MLA：
Zhang, Yulin,et al."Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality".INFECTION and DRUG RESISTANCE 13.(2020):4115-4123
