单位：[1]Graduate School, Beijing University of Chinese Medicine, Beijing, China[2]International Medical Services, China-Japan Friendship Hospital, Beijing, China[3]Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China[4]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China
Background We aimed to identify potential risk factors for recurrent respiratory tract infection among Chinese preschool-aged children, and further to construct a nomogram prediction model. Methods This is a cross-sectional survey conducted in Beijing. Utilizing a stratified cluster random sampling strategy, a total of 7222 children from 20 kindergartens were enrolled. Data are analyzed by STATA software and R language. Results Five independent factors were identified to be significantly associated with recurrent respiratory tract infection risk overall and by pathogenic sites. The significant odds of recurrent respiratory tract infection was 8.31 (95% confidence interval [CI]: 5.69-12.12, P < 0.001), 2.31 (2.06-2.58, P < 0.001), 1.72 (1.48-1.99, P < 0.001), 1.24 (1.08-1.43, P = 0.002), and 1.19 (1.09-1.31, P < 0.001) for asthma, allergy, initial use of antibiotics <6 months, breastfeeding duration <6 months, and maternal body mass index, respectively. Besides the leading role played by asthma, allergy, initial use of antibiotics, and breastfeeding might exert a graded, dose-dependent effect on recurrent respiratory tract infection susceptibility. Conclusions We have identified five potential risk factors for the risk of recurrent respiratory tract infection from 7222 preschool-aged Chinese children. Notably, asthma plays a leading role, and allergy, initial use of antibiotics, and breastfeeding might exert a graded, dose-dependent effect on recurrent respiratory tract infection susceptibility. Impact This is the first report of examining the joint contribution of multiple potential risk factors to recurrent respiratory tract infection among Chinese preschool-aged children. We have identified five potential risk factors for the risk of recurrent respiratory tract infection via analyzing survey data from 7222 preschool-aged Chinese children. Asthma plays a leading role, and allergy, initial use of antibiotics, and breastfeeding might exert a graded, dose-dependent effect on recurrent respiratory tract infection susceptibility.
第一作者单位：[1]Graduate School, Beijing University of Chinese Medicine, Beijing, China[2]International Medical Services, China-Japan Friendship Hospital, Beijing, China[3]Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[2]International Medical Services, China-Japan Friendship Hospital, Beijing, China[3]Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China
推荐引用方式(GB/T 7714)：
Zhou Bo,Niu Wenquan,Liu Fangyu,et al.Risk factors for recurrent respiratory tract infection in preschool-aged children[J].PEDIATRIC RESEARCH.2021,90(1):223-231.doi:10.1038/s41390-020-01233-4.
APA：
Zhou, Bo,Niu, Wenquan,Liu, Fangyu,Yuan, Yuan,Wang, Kundi...&Zhang, Zhixin.(2021).Risk factors for recurrent respiratory tract infection in preschool-aged children.PEDIATRIC RESEARCH,90,(1)
MLA：
Zhou, Bo,et al."Risk factors for recurrent respiratory tract infection in preschool-aged children".PEDIATRIC RESEARCH 90..1(2021):223-231
