单位：[a]Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China[b]Department of Radiology, Beijing Jishuitan Hospital, Beijing, China[c]Department of Health Center, Yijishan Hospital ofWannan Medical College, Wuhu, China[d]Department of Health Management, The Affiliated Hospital of Guizhou Medical University, Guiyang, China[e]Department of Health Management, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China[f]Department of Radiology, The Affiliated Huashan Hospital of Fudan University, Shanghai, China[g]Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[h]Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China[i]Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[j]Department of Radiology, Ningbo Medical Center Li Huili Hospital, Ningbo, China[k]Department of CT, The First Affiliated Hospital of Harbin Medical University, Harbin, China[l]Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China[m]Department of Health Management, China-Japan Friendship Hospital, Beijing, China[n]Department of Radiology, The People's Hospital of Zhengjiang Province, Hangzhou, China[o]Department of Radiology, Southwest Hospital, Army Medical University, Chongqing, China[p]Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China[q]Department of Radiology, Yijishan Hospital ofWannan Medical College, Wuhu, China[r]Department of Medical Record Management and Statistics, Beijing Jishuitan Hospital, Beijing, China[s]National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China[t]School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London SE1 7EH, United Kingdom[u]Department of Radiology, Beijing PUMC Hospital, Beijing, China[v]Editorial Office of the Chinese Health Management Journal, Beijing, China[w]Orthopedic Institute of Henan Province, Zhengzhou, China[x]Québec Heart and Lung Institute, Québec City, QC, Canada[y]Department of Kinesiology, Faculty of Medicine, Université Laval, Québec City, QC, Canada
Background: Although abdominal adiposity is associated with an altered carcliometabolic risk profile, the specific contribution of abdominal adipose tissue distribution remains not fully understood. Computed tomography (CF) is a well-established and precise method to measure alxlominal adipose tissue distribution. The present study investigated abdominal adiposity assessed by CT in a large-scale Chinese population. Method: A total of 59,429 adults who underwent a low dose chest CT for lung cancer screening at one of 13 health checkup centers throughout China were evaluated. Abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured at the center of the 2nd lumbar vertebra with Mindways quantitative CT software using the existing CT dataset without any additional radiation exposure. The ratio of visceral to total adipose tissue (TAT) areas (VAT/TAT ratio) was calculated and expressed as a percentage. Anthropometric indices including body mass index (BMI) and waist circumference were also obtained. Results: BMI, waist circumference, VAT area, SAT area, and the VAT/TAT ratio were 25.0 +/- 3.0 kg/m(2), 90 +/- 8 cm, 194 = 77 cm(2), 85 +/- 41 cm(2), and 69.5 +/- 9.1%, respectively, in men and 23.3 +/- 3.1 kg/m(2) , 79 +/- 8 cm, 120 +/- 57 cm(2), 123 +/- 53 cm(2). and 48.9 +/- 9.7% in women. With increasing age, VAT area and the VAT/TAT ratio increased in both sexes whereas SAT area decreased in men (P < 0.001 for all). After adjustment for BMI and waist circumference, older individuals showed higher VAT area and higher VAT/TAT ratio than younger subjects (P < 0.001 for all). Adjusted VAT areas in participants aged 75 or older was 45 cm(2) (95% confidence interval [CI]: 41 cm(2) , 50 cm(2)) higher in men and 43 cm(2) (95% CI: 37 cm(2) , 49 cm(2)) higher in women compared with participants aged 31-44 years. Additionally, differences in VAT area across age groups increased as BMI or waist circumference increased. VAT and SAT areas, but not the VAT/TAT ratio, were positively associated with BMI and waist circumference in every age group. Conclusion: In a nationwide study conducted in China, distributions of CT-derived measures of visceral and subcutaneous adiposity were found to vary significantly between sex and age groups. Our study also revealed that the proportion of VAT (an important driver of cardiometabolic risk) could not be predicted from BMI in a Chinese population. (C) 2020 The Authors. Published by Elsevier Inc.
基金：
Beijing Natural Science Foundation-Haidian Primitive Innovation Joint Fund [L172019]
第一作者单位：[a]Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[x]Québec Heart and Lung Institute, Québec City, QC, Canada[y]Department of Kinesiology, Faculty of Medicine, Université Laval, Québec City, QC, Canada[*1]Québec Heart and Lung Institute, Québec City, QC, Canada
推荐引用方式(GB/T 7714)：
Qiang Zeng,LingWang,Shengyong Dong,et al.CT-derived abdominal adiposity: Distributions and better predictive ability than BMI in a nationwide study of 59,429 adults in China[J].METABOLISM-CLINICAL and EXPERIMENTAL.2021,115:doi:10.1016/j.metabol.2020.154456.
APA：
Qiang Zeng,LingWang,Shengyong Dong,Xiaojuan Zha,Limei Ran...&Xiaoguang Cheng.(2021).CT-derived abdominal adiposity: Distributions and better predictive ability than BMI in a nationwide study of 59,429 adults in China.METABOLISM-CLINICAL and EXPERIMENTAL,115,
MLA：
Qiang Zeng,et al."CT-derived abdominal adiposity: Distributions and better predictive ability than BMI in a nationwide study of 59,429 adults in China".METABOLISM-CLINICAL and EXPERIMENTAL 115.(2021)
医学