Association between LXR-alpha and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population
单位：[1]Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital, Beijing, China [2]Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China [3]Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China- Japan Friendship Hospital, Beijing, China
We designed a case-control study and selected LXR-alpha rs7120118 C>T and ABCA1 rs2230806 A>G polymorphisms to determine the correlation between these polymorphisms and diabetic kidney disease (DKD) susceptibility in a Chinese Han population. Three hundred DKD patients and 346 type 2 diabetes mellitus (DM) patients without kidney disease were recruited. Our results showed that rs7120118 was associated with DKD (genotype, P=.027; allele, P<.011). rs7120118 was associated with a higher risk of DKD under a dominant model adjustment by age and sex (P=.015) and an additive model (P=.040); rs2230806 was associated with a higher risk of DKD under an recessive model (P<.03); the combined effect of rs7120118 CC+rs2230806 GG genotype showed an association of DKD adjustment for age and sex (P=.009). In subgroup analysis of patients without hypercholesterolemia, the rs2230806 genotype frequencies were different between the two groups (P=.042). rs2230806 was associated with increased risk of DKD under a recessive model adjustment for age and sex (P=.013) and an additive model (P=.031). Our results suggest that LXR-alpha rs7120118 is significantly associated with a higher risk of DKD, and ABCA1 rs2230806 is significantly associated with a higher risk of DKD without hypercholesterolemia in Chinese Han individuals.
基金：
Research Projects of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [8190152536]; National Natural Science Foundation of China (region) cooperation and exchange projectNational Natural Science Foundation of China (NSFC) [81620108031]; biomedical transformation project of China-Japan Friendship Hospital [PYBZ1829]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区医学：研究与实验4 区内分泌学与代谢
最新[2025]版：
大类|3 区医学
小类|3 区内分泌学与代谢3 区医学：研究与实验
JCR分区：
出版当年[2018]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ3ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q2ENDOCRINOLOGY & METABOLISMQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Shunyi Hospital, Beijing Traditional Chinese Medicine Hospital, Beijing, China
共同第一作者：
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推荐引用方式(GB/T 7714)：
Liu Peng,Ma Liang,Zhao Hailing,et al.Association between LXR-alpha and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population[J].JOURNAL of DIABETES RESEARCH.2020,2020:doi:10.1155/2020/8721536.
APA：
Liu, Peng,Ma, Liang,Zhao, Hailing,Shen, Zhengri,Zhou, Xuefeng...&Li, Ping.(2020).Association between LXR-alpha and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population.JOURNAL of DIABETES RESEARCH,2020,
MLA：
Liu, Peng,et al."Association between LXR-alpha and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population".JOURNAL of DIABETES RESEARCH 2020.(2020)
