单位：[1]Institute of Medical Technology, Peking University Health Science Center, Beijing, China[2]Peking University Third Hospital, Beijing, China[3]Postgraduate School, Dalian Medical University, Dalian, China[4]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China[5]Department of Clinical Medicine, School of Clinical Medicine, Bengbu Medical College, Bengbu, China[6]Department of Urology, Peking University Cancer Hospital & Institute, Beijing, China[7]Department of Orthopedics, Peking University International Hospital, Beijing, China[8]School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China[9]Department of Spine Surgery, China-Japan Friendship Hospital, Beijing, China
Objective. To evaluate the efficacy and safety of different dose regimens of intravenous (IV) tranexamic acid (TXA) in adolescent spinal deformity surgery. Methods. Two researchers independently searched multiple databases, including PubMed, Embase, Cochrane Library, and Web of Science to find studies that met the inclusion criteria. A meta-analysis was performed based on the guidelines of the Cochrane Reviewer's Handbook. Results. Six randomized controlled trials (RCTs) and eleven non-RCTs were identified, including 1148 patients. According to different dose regimens of IV TXA, the included studies were divided into the high-dose group and the low-dose group. Compared with placebo, both groups had less total blood loss (TBL) (high dose: WMD=-1737.55, 95% CI: (-2247.16, -1227.94), P<0.001, I-2=0%; low dose: WMD=-528.67, 95% CI: (-666.06, -391.28), P<0.001, I-2=0%), intraoperative blood loss (IBL) (high dose: WMD=-301.48, 95% CI: (-524.3, -78.66), P=0.008, I-2=60.3%; low dose: WMD=-751.14, 95% CI: (-967.21, -535.08), P<0.001, I-2=0%), and blood transfusion rates (high dose: RR=0.19, 95% CI: (0.1, 0.37), P<0.001, I-2=0%; low dose: RR=0.4, 95% CI: (0.18, 0.91), P=0.029, I-2=57%). High-dose IV TXA use was associated with more vertebral fusion segments (WMD=0.53, 95% CI: (0.23, 0.82), P<0.001, I-2=31.2%). Low-dose IV TXA use was associated with shorter operative time (WMD=-18.43, 95% CI: (-26.68, -10.17), P<0.001, I-2=0%). Conclusion. High-dose and low-dose IV TXA were effective in reducing TBL, IBL, and blood transfusion rates without increasing complications in adolescent patients undergoing spinal deformity surgery. Low-dose IV TXA was effective in reducing the operative time. Both the high-dose and low-dose groups had similar preoperative and postoperative Hb levels compared to the control group.
基金：
Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z181100001818006]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
JCR分区：
出版当年[2018]版：
Q3MEDICINE, RESEARCH & EXPERIMENTALQ3BIOTECHNOLOGY & APPLIED MICROBIOLOGY
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Institute of Medical Technology, Peking University Health Science Center, Beijing, China[2]Peking University Third Hospital, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Medical Technology, Peking University Health Science Center, Beijing, China[7]Department of Orthopedics, Peking University International Hospital, Beijing, China[8]School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China
推荐引用方式(GB/T 7714)：
Xiong Zhencheng,Wu Kexin,Zhang Jiayu,et al.Different Dose Regimens of Intravenous Tranexamic Acid in Adolescent Spinal Deformity Surgery: A Systematic Review and Meta-Analysis[J].BIOMED RESEARCH INTERNATIONAL.2020,2020:doi:10.1155/2020/3101358.
APA：
Xiong, Zhencheng,Wu, Kexin,Zhang, Jiayu,Leng, Delong,Yu, Ziyi...&Yi, Ping.(2020).Different Dose Regimens of Intravenous Tranexamic Acid in Adolescent Spinal Deformity Surgery: A Systematic Review and Meta-Analysis.BIOMED RESEARCH INTERNATIONAL,2020,
MLA：
Xiong, Zhencheng,et al."Different Dose Regimens of Intravenous Tranexamic Acid in Adolescent Spinal Deformity Surgery: A Systematic Review and Meta-Analysis".BIOMED RESEARCH INTERNATIONAL 2020.(2020)
