单位：[1]State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China[2]Department of General Surgery, China−Japan Friendship Hospital, Beijing 100029, China[3]School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
Accurate discrimination of cancerous cells is a good solution for early diagnosis of tumors. The mitochondrion plays an important role in cells. Herein, the five aggregation-induced emission luminogens (AIEgens) with various double positive charges are synthesized to image mitochondria. Tetraphenylethylene (TPE) molecules are modified by methoxy groups, conjugated donor-acceptor, and different positive charges to achieve multicolor emission. The five AIEgens form the PTx-Sa (positive mitochondria-target molecular sensor array) to perform cross-fluorescence response based on the mitochondria-targeted imaging to achieve the discrimination of various cells. Principal component analysis of the cross-response fluorescence data of PTx-Sa shows that 100% accurate identification of various cells, including cancer cells and normal cells, digestive tract cancer cells, gastric cancer cells, and mixed gastric cancer cells. By support vector machine to show the predictive ability of PTx-Sa to unknown cells by using blind samples. This is the first time to apply mitochondria-targeted sensor array to identification of various cells.
基金：
Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21775010, 11811530639, 81961138011]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7192106]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [XK1901, PT2026]
第一作者单位：[1]State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
通讯作者：
通讯机构：[1]State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China[2]Department of General Surgery, China−Japan Friendship Hospital, Beijing 100029, China[3]School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China[*1]State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China[*2]Department of General Surgery, China−Japan Friendship Hospital, Beijing 100029, China[*3]School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式(GB/T 7714)：
Ma Yufan,Ai Wenting,Huang Jia,et al.Mitochondria-Targeted Sensor Array with Aggregation-Induced Emission Luminogens for Identification of Various Cells[J].ANALYTICAL CHEMISTRY.2020,92(21):14444-14451.doi:10.1021/acs.analchem.0c02426.
APA：
Ma, Yufan,Ai, Wenting,Huang, Jia,Ma, Lijun,Geng, Yujie...&Wang, Zhuo.(2020).Mitochondria-Targeted Sensor Array with Aggregation-Induced Emission Luminogens for Identification of Various Cells.ANALYTICAL CHEMISTRY,92,(21)
MLA：
Ma, Yufan,et al."Mitochondria-Targeted Sensor Array with Aggregation-Induced Emission Luminogens for Identification of Various Cells".ANALYTICAL CHEMISTRY 92..21(2020):14444-14451
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