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Possible immune regulation mechanisms for the progression of chronic thromboembolic pulmonary hypertension

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收录情况： ◇ SCIE

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单位： [a]Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China [b]Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing, 100020, China [c]Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China [d]Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China [e]Department of Pathology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China [f]Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China [g]Department of Echocardiography, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China [h]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, 100029, China [i]Department of Radiology, China-Japan Friendship Hospital, Beijing, 100029, China [j]Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China

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关键词： Chronic thromboembolic pulmonary hypertension Differentially expressed gene Immune cell Circular RNA microRNA

摘要：

Purpose: This study aimed to screen key genes significantly associated with chronic thromboembolic pulmonary hypertension (CTEPH) and predicted suitable drugs for the treatment of CTEPH from the perspective of immune cells. Methods: The dataset GSE130391 was used for this analysis. Differentially expressed genes (DEGs) between the CTEPH and control groups were screened. Abundance of infiltrating immune cells was analyzed and immune related DEGs were identified. Next, the circular RNA (circRNA)-micro RNA (miRNA)-mRNA network was constructed, followed by functional enrichment analysis. Then, the protein-protein interaction (PPI) network was constructed and drug-gene interactions were predicted. Finally, miRNA and circRNA prediction results were verified by our previously published studies. Results: Five key immune cell-related DEGs [CD83 molecule (CD83), complement c5a receptor 1 (C5AR1), atypical chemokine receptor 1 (ACKR1), profilin 2 (PFN2), and solute carrier family 2 member 3 (SLC2A3)] were identified. Several circRNA-miRNA-mRNA interactions were obtained, including circ_0022342-miR-5035p-SLC2A3 and circ_0002062-miR-92b-3p/miR-92a-3p-mannosidase alpha class 2A member 1 (MAN2A1). Immune cell for SLC2A3 was eosinophils and for MAN2A1 was regulatory T cells (Tregs). Additionally, Glufosfamide and Kifunensine might be suitable as candidate drugs for CTEPH treatment. Conclusions: SLC2A3 and MAN2A1 may be important genes for the pathogenesis of CTEPH. Possible immune regulation mechanisms in CTEPH may be circ_0022342-miR-503-5p-SLC2A3 and circ_0002062-miR-92b-3p/miR-92a-3p-MAN2A1. These results may be helpful for the diagnosis and treatment of CTEPH from the perspective of immunology.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区血液学 3 区外周血管病

最新[2025]版：

大类 | 3 区医学

小类 | 2 区血液学 3 区外周血管病

JCR分区：

出版当年[2019]版：

Q2 PERIPHERAL VASCULAR DISEASE Q2 HEMATOLOGY

最新[2023]版：

Q1 HEMATOLOGY Q1 PERIPHERAL VASCULAR DISEASE

影响因子： 最新[2023版] 3.7 最新五年平均[2021-2025] 4.1 出版当年[2019版] 2.869 出版当年五年平均[2015-2019] 2.621 出版前一年[2018版] 3.266 出版后一年[2020版] 3.944

第一作者：

第一作者单位： [a]Medical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China [b]Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing, 100020, China

通讯作者：

通讯机构： [b]Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing, 100020, China [d]Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China [j]Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China [*1]Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Capital Medical University, No.8 South Gongti Road, Beijing 100020, China. [*2]Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, No.8 South Gongti Road, Beijing 100020, China.

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Possible immune regulation mechanisms for the progression of chronic thromboembolic pulmonary hypertension

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