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circGFRA1 affects the sensitivity of triple-negative breast cancer cells to paclitaxel via the miR-361-5p/TLR4 pathway

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收录情况： ◇ SCIE

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单位： [1]Capital Med Univ, Beijing Friendship Hosp, Beijing Key Lab Canc Invas & Metastasis Res, Dept Gen Surg, 95 Yong An Rd, Beijing 100050, Peoples R China [2]Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, 95 Yong An Rd, Beijing 100050, Peoples R China [3]Wenzhou Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Wenzhou 325000, Zhejiang, Peoples R China [4]Wenzhou Med Univ, Affiliated Hosp 1, Dept Colorectal & Anal Surg, Wenzhou 325000, Zhejiang, Peoples R China

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关键词： circGFRA1 miR-361-5p PTX TLR4 triple-negative breast cancerNatural Science Foundation of Zhejiang Province of China [LY19H160026] Zhejiang Provincial Health Department [2019KY454] Wenzhou Bureau of Science and Technology [Y20170038 Y20170257]

摘要：

In recent years, the role of circular RNAs (circRNAs) in tumours has attracted widespread attention. Some circRNAs have been reported to play a role in triple-negative breast cancer (TNBC). However, circRNAs have rarely been reported in terms of TNBC resistance. This study aimed to clarify that circGFRA1 affects the sensitivity of TNBC cells to paclitaxel (PTX) by the miR-361-5p/TLR4 pathway. Compared with the non-PTX-resistant TNBC cell line MDA-MB-231, the expression of circGFRA1 in the PTX-resistant TNBC cell line MDA-MB-231.PR was significantly increased. The small hairpin RNA-mediated circGFRA1 knockdown inhibited the resistance of TNBC cells to PTX. RNA pull-down assay and luciferase reporter gene assay confirmed the binding between circGFRA1 and miR-361-5p and between miR-361-5p and TLR4. It has been proven that circGFRA1 knockdown can inhibit the resistance of TNBC cells to PTX by promoting the expression of miR-361-5p, and subsequently reduce the expression of TLR4.

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出版当年[2020]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学

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出版当年[2019]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 2.1 最新五年平均[2021-2025] 2.2 出版当年[2019版] 2.476 出版当年五年平均[2015-2019] 2.381 出版前一年[2018版] 2.23 出版后一年[2020版] 3.387

第一作者：

第一作者单位： [1]Capital Med Univ, Beijing Friendship Hosp, Beijing Key Lab Canc Invas & Metastasis Res, Dept Gen Surg, 95 Yong An Rd, Beijing 100050, Peoples R China [2]Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, 95 Yong An Rd, Beijing 100050, Peoples R China [3]Wenzhou Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Wenzhou 325000, Zhejiang, Peoples R China

通讯作者：

通讯机构： [1]Capital Med Univ, Beijing Friendship Hosp, Beijing Key Lab Canc Invas & Metastasis Res, Dept Gen Surg, 95 Yong An Rd, Beijing 100050, Peoples R China [2]Capital Med Univ, Beijing Friendship Hosp, Natl Clin Res Ctr Digest Dis, 95 Yong An Rd, Beijing 100050, Peoples R China

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