Regulatory Role of the RNA N-6-Methyladenosine Modification in Immunoregulatory Cells and Immune-Related Bone Homeostasis Associated With Rheumatoid Arthritis
单位：[1]Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China,[2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China,[3]School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China,[4]Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China,[5]Clinical Medical School (China-Japan Friendship Hospital), Beijing University of Chinese Medicine, Beijing, China,[6]Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan,[7]Department of Plastic Surgery, China-Japan Friendship Hospital, Beijing, China,[8]Department of Emergency, China-Japan Friendship Hospital, Beijing, China
Rheumatoid arthritis (RA) is a systemic autoimmune disease for which the etiology has not been fully elucidated. Previous studies have shown that the development of RA has genetic and epigenetic components. As one of the most highly abundant RNA modifications, the N-6-methyladenosine (m(6)A) modification is necessary for the biogenesis and functioning of RNA, and modification aberrancies are associated with various diseases. However, the specific functions of m(6)A in the cellular processes of RA remain unclear. Recent studies have revealed the relationship between m(6)A modification and immune cells associated with RA. Therefore, in this review, we focused on discussing the functions of m(6)A modification in the regulation of immune cells and immune-related bone homeostasis associated with RA. In addition, to gain a better understanding of the progress in this field of study and provide the proper direction and suggestions for further study, clinical application studies of m(6)A modification were also summarized.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82073677, 81673844, 81873223, 82074269]
第一作者单位：[1]Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China,[2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China,[2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China,[8]Department of Emergency, China-Japan Friendship Hospital, Beijing, China
推荐引用方式(GB/T 7714)：
Fan Danping,Xia Ya,Lu Cheng,et al.Regulatory Role of the RNA N-6-Methyladenosine Modification in Immunoregulatory Cells and Immune-Related Bone Homeostasis Associated With Rheumatoid Arthritis[J].FRONTIERS in CELL and DEVELOPMENTAL BIOLOGY.2021,8:doi:10.3389/fcell.2020.627893.
APA：
Fan, Danping,Xia, Ya,Lu, Cheng,Ye, Qinbin,Xi, Xiaoyu...&Xiao, Cheng.(2021).Regulatory Role of the RNA N-6-Methyladenosine Modification in Immunoregulatory Cells and Immune-Related Bone Homeostasis Associated With Rheumatoid Arthritis.FRONTIERS in CELL and DEVELOPMENTAL BIOLOGY,8,
MLA：
Fan, Danping,et al."Regulatory Role of the RNA N-6-Methyladenosine Modification in Immunoregulatory Cells and Immune-Related Bone Homeostasis Associated With Rheumatoid Arthritis".FRONTIERS in CELL and DEVELOPMENTAL BIOLOGY 8.(2021)
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