单位：[1]Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China[2]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China
Background: Hydrogen was proven to have anti-oxidative and anti-inflammation effects to various diseases. Aim: We wish to investigate the acute effects of inhaled hydrogen on airway inflammation in patients with asthma and chronic obstructive pulmonary disease (COPD). Design: Prospective study. Methods: In total, 2.4% hydrogen containing steam mixed gas (XEN) was inhaled once for 45min in 10 patients with asthma and 10 patients with COPD. The levels of granulocyte-macrophage colony stimulating factor, interferon-gamma, interleukin-1 beta (IL-1 beta), IL-2, IL-4, IL-6 and so on in peripheral blood and exhaled breath condensate (EBC) before and after `XEN' inhalation were measured. Results: 45 minutes 'XEN' inhalation once decreased monocyte chemotactic protein 1 level in both COPD (564.70451.51 pg/mL, P = 0.019) and asthma (386.39-332.76 pg/mL, P = 0.033) group, while decreased IL-8 level only in asthma group (5.25-4.49 pg/mL, P = 0.023). The level of EBC soluble cluster of differentiation-40 ligand in COPD group increased after inhalation (1.07-1.16 pg/mL, P = 0.031), while IL-4 and IL-6 levels in EBC were significantly lower after inhalation in the COPD (0.80-0.64 pg/mL, P = 0.025) and asthma (0.06-0.05 pg/mL, P = 0.007) group, respectively. Conclusions: A single inhalation of hydrogen for 45 min attenuated inflammatory status in airways in patients with asthma and COPD.
基金：
National Key Research and Development Program of China [2018YFC1313600]; National Key Basic Research Program of China (973 Program)National Basic Research Program of China [2015CB553402]
第一作者单位：[1]Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China[*1]Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, #1 Shuaifuyuan Hutong, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Wang S-T,Bao C.,He Y.,et al.Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients[J].QJM-AN INTERNATIONAL JOURNAL of MEDICINE.2020,113(12):870-875.doi:10.1093/qjmed/hcaa164.
APA：
Wang, S-T,Bao, C.,He, Y.,Tian, X.,Yang, Y....&Xu, K-F.(2020).Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients.QJM-AN INTERNATIONAL JOURNAL of MEDICINE,113,(12)
MLA：
Wang, S-T,et al."Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients".QJM-AN INTERNATIONAL JOURNAL of MEDICINE 113..12(2020):870-875
