Impact of neoadjuvant chemotherapy on the postoperative pathology of locally advanced cervical squamous cell carcinomas: 1:1 propensity score matching analysis
单位：[1]Department of Obstetrics and Gynecology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong, China[2]Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, Shangxi, China[3]Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Zhengzhou University, Henan, China[4]Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, China河北医科大学第四医院[5]Department of Obstetrics and Gynecology, Daping Hospital, Army Medical University, Chonqing, China[6]Department of Obstetrics and Gynecology, Xinqiao Hospital, Army Medical University, Chongqing, China[7]Department of Obstetrics and Gynecology, Yuncheng Central Hospital, Yuncheng, China[8]Department of Gynaecology, Anhui Cancer Hospital, HeFei, China[9]Department of Gynecology, The Maternity and Child Care Hospital of Guizhou Province, Guiyang, China[10]Department of Obstetrics and Gynecology, China-Japan Friendship Hospital, Beijing, China[11]Department of Obstetrics and Gynecology, Guizhou Provincial People’s Hospital, Guiyang, China[12]Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
Objective: To assess the impact of neoadjuvant chemotherapy on postoperative pathology for stage IB2 and IIA2 cervical squamous cell carcinoma. Methods: Postoperative pathology was compared between patients who received neoadjuvant chemotherapy followed by radical hysterectomy (NACT group) and patients who received upfront radical hysterectomy (URH group). Then, patients in the NACT group were divided into a chemotherapy-sensitive group and a chemotherapy-insensitive group according to their response to chemotherapy. Results: After 1:1 propensity score matching (PSM), the positive rates of lymphovascular space invasion (LVSI) (7.9% vs 17.7%, P = 0.001) and cervical deep stromal invasion (60.4% vs 76.2%, P < 0.001) in the NACT group were significantly lower than those in the URH group, while the positive rates of parametrial invasion, lymph node metastasis, and vaginal margin invasion were not significantly different between the two groups. The rate of positive lymph node metastasis in the chemotherapy-sensitive group was significantly lower than that in the URH group (18.1% vs 26.5%, P = 0.037). Conclusion: Among patients with stage IB2 and IIA2 cervical squamous cell carcinomas, NACT can reduce the positive rate of intermediate-risk factors, such as deep cervical stromal invasion and LVSI, but cannot reduce the positive rate of high-risk factors. For patients who are chemotherapy sensitive, NACT can reduce the positive rate of lymph node metastasis. (C) 2020 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
基金：
National Science and Technology Support Program of China [2014BAI05B03]; National Natural Science Fund of GuangdongNational Natural Science Foundation of Guangdong Province [2015A030311024]; Science and Technology Plan of Guangzhou [158100075]; Center Hospital of Liberation Army/Hospital [153]; Chinese People's Liberation Army [988]
第一作者单位：[1]Department of Obstetrics and Gynecology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Obstetrics and Gynecology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong, China[*1]Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, Guangzhou, 510515, China
推荐引用方式(GB/T 7714)：
Li Pengfei,Fang Ziyu,Li Weili,et al.Impact of neoadjuvant chemotherapy on the postoperative pathology of locally advanced cervical squamous cell carcinomas: 1:1 propensity score matching analysis[J].EJSO.2021,47(5):1069-1074.doi:10.1016/j.ejso.2020.09.013.
APA：
Li Pengfei,Fang Ziyu,Li Weili,Hao Min,Wang Wuliang...&Liu Ping.(2021).Impact of neoadjuvant chemotherapy on the postoperative pathology of locally advanced cervical squamous cell carcinomas: 1:1 propensity score matching analysis.EJSO,47,(5)
MLA：
Li Pengfei,et al."Impact of neoadjuvant chemotherapy on the postoperative pathology of locally advanced cervical squamous cell carcinomas: 1:1 propensity score matching analysis".EJSO 47..5(2021):1069-1074
