单位：[1]Department of Neurology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.[2]The Second Affiliated Hospital of Soochow University, Suzhou, China.苏州大学附属第二医院[3]Fujian Medical University Union Hospital, Fuzhou, China.[4]Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China[5]China-Japan Friendship Hospital, Beijing, China[6]West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院[7]The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.中山大学附属第一医院[8]Beijing Friendship Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京友谊医院[9]Xiangya Hospital of Central South University, Changsha, Hunan, China.[10]The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.深圳医学信息中心香港大学深圳医院[11]GSK, Mumbai, India.[12]GSK, Brentford, Middlesex, UK.[13]GSK, Shanghai, China
Background: The impact of nocturnal disturbance (ND) in Parkinson's disease on quality of life of patients in Western Countries is increasingly understood. Our study aimed to investigate ND prevalence and its quality of life impact in patients with advanced Parkinson's disease in China. Methods: In a multicenter, tertiary-care hospital, outpatient-based, cross-sectional study, patients with advanced Parkinson's disease (Modified Hoehn & Yahr [H&Y] Stage II-IV with >= 3 h awake "off" time/day) from 10 tertiary hospitals throughout China completed the Parkinson's Disease Sleep Scale-2 (PDSS-2) and Parkinson's Disease Questionnaire-39 (PDQ-39). The primary endpoint was the percentage of patients with significant ND (PDSS-2 total score >= 15). Additional endpoints were demographic and clinical characteristics, PDSS-2 and PDQ-39 total and subscale scores, correlation between PDSS-2 and PDQ-39, and risk factors for ND and higher PDSS-2 or PDQ-39 scores. Results: Of 448 patients analyzed (mean age 63.5 years, 47.3% female), 70.92% (95% confidence interval: 66.71, 75.13) had significant ND. Presence of ND and higher PDSS-2 scores were associated with longer disease duration and higher H&Y stage. Presence of ND was also associated with more awake "off" time/day and female sex. PDQ-39 scores were significantly worse for patients with ND versus those without ND; worse scores were associated with more awake "off" time/day, female sex, and higher H&Y stage. PDSS-2 and PDQ-39 total scores were associated: Pearson correlation coefficient 0.62 (p < 0.001). Conclusions: In China, ND was highly prevalent in patients with advanced Parkinson's disease and adversely impacted quality of life. This study highlights the importance of early diagnosis and optimized management of ND in patients with Parkinson's disease in China.
第一作者单位：[1]Department of Neurology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Guiying He,Chun-Feng Liu,Qinyong Ye,et al.Prevalence and profile of nocturnal disturbances in Chinese patients with advanced-stage Parkinson's disease: a cross-sectional epidemiology study[J].BMC NEUROLOGY.2021,21(1):doi:10.1186/s12883-021-02217-5.
APA：
Guiying He,Chun-Feng Liu,Qinyong Ye,Zhenguo Liu,Miao Jin...&Shengdi Chen.(2021).Prevalence and profile of nocturnal disturbances in Chinese patients with advanced-stage Parkinson's disease: a cross-sectional epidemiology study.BMC NEUROLOGY,21,(1)
MLA：
Guiying He,et al."Prevalence and profile of nocturnal disturbances in Chinese patients with advanced-stage Parkinson's disease: a cross-sectional epidemiology study".BMC NEUROLOGY 21..1(2021)
