单位：[1]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China[2]National Research Center for Rehabilitation Technical Aids, Beijing 100176, China[3]Centre for Osteonecrosis & Joint-preserving & Reconstruction, China-Japan Friendship Hospital, Beijing 100191, China
Measuring the location of necrotic lesions is necessary to diagnosis of osteonecrosis. Different region seg-mentation methods of the femoral head were proposed to quantitatively measure necrotic lesions includ-ing Japanese Investigation Committee for Avascular Necrosis (JIC) classification and China-Japan Friendship Hospital (CJFH) classification. Biomechanical methods could bring important information to evaluate the reasonability of these classifications. In this study, microstructural and mechanical proper-ties of trabecular bone were quantitatively analyzed according to the region segmentation methods described in these classifications. Microstructural parameters of trabecular bone were analyzed based on micro-CT scanning. Mechanical properties were measured through Nanoindentation and micro-finite element analysis. It was found that microstructural and mechanical properties of trabecular bone in the middle region was more adaptive to load bearing than the medial and lateral regions according to the CJFH classification; lesions in the middle region could bring more changes to microstructure and stress distribution. According to JIC classification, differences of microstructural and mechanical properties among the three regions were not significant. Biomechanical characteristics of trabecular bones could be better distinguished with CJFH classification. ? 2021 Elsevier Ltd. All rights reserved.
基金：
National Key Research and Development Project [2017YFB1304101]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11421202, 11822201, 61761166002, 81372013]; China-Japan Friendship Hospital Youth Science and technology excellence project [2014-QNYC-A-06]; 111 ProjectMinistry of Education, China - 111 Project [B13003]
第一作者单位：[1]Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China
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推荐引用方式(GB/T 7714)：
Feng Chenglong,Wang Lizhen,Xu Peng,et al.Microstructural and mechanical evaluations of region segmentation methods in classifications of osteonecrosis[J].JOURNAL of BIOMECHANICS.2021,119:doi:10.1016/j.jbiomech.2020.110208.
APA：
Feng, Chenglong,Wang, Lizhen,Xu, Peng,Chu, Zhaowei,Yao, Jie...&Fan, Yubo.(2021).Microstructural and mechanical evaluations of region segmentation methods in classifications of osteonecrosis.JOURNAL of BIOMECHANICS,119,
MLA：
Feng, Chenglong,et al."Microstructural and mechanical evaluations of region segmentation methods in classifications of osteonecrosis".JOURNAL of BIOMECHANICS 119.(2021)
