单位：[1]Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China临床科室口腔科口腔科首都医科大学附属北京友谊医院[2]Department of Stomatology, China-Japan Friendship Hospital, Beijing 100029, China[3]Department of Physics, University of Münster, Wilhelm-Klemm-Str. 9, 48149 Münster, Germany[4]Department of Cariology, Endodontology and Periodontology, University Leipzig, Liebigstr. 12, Leipzig 04103, Germany[5]Department of Neurology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan[6]Dr. D Y Patil Dental College and Hospital, Dr D Y Patil Vidyapeeth, Pimpri, Pune, India[7]Faculty of Electrical Engineering, Information Technology, and Physics, University Braunschweig, Hans-Sommer-Str. 66, Braunschweig 38106, Germany[8]Laboratory of Molecular Cell Biology, Beijing Tibetan Hospital, China Tibetology Research Center, 218 Anwaixiaoguanbeili Street, Chaoyang, Beijing 100029, China[9]Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China南方医科大学珠江医院[10]Department of Neurology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 10091 Shandong Province, China
Objective. To investigate the genetic crosstalk mechanisms that link periodontitis and Alzheimer's disease (AD). Background. Periodontitis, a common oral infectious disease, is associated with Alzheimer's disease (AD) and considered a putative contributory factor to its progression. However, a comprehensive investigation of potential shared genetic mechanisms between these diseases has not yet been reported. Methods. Gene expression datasets related to periodontitis were downloaded from the Gene Expression Omnibus (GEO) database, and differential expression analysis was performed to identify differentially expressed genes (DEGs). Genes associated with AD were downloaded from the DisGeNET database. Overlapping genes among the DEGs in periodontitis and the AD-related genes were defined as crosstalk genes between periodontitis and AD. The Boruta algorithm was applied to perform feature selection from these crosstalk genes, and representative crosstalk genes were thus obtained. In addition, a support vector machine (SVM) model was constructed by using the scikit-learn algorithm in Python. Next, the crosstalk gene-TF network and crosstalk gene-DEP (differentially expressed pathway) network were each constructed. As a final step, shared genes among the crosstalk genes and periodontitis-related genes in DisGeNET were identified and denoted as the core crosstalk genes. Results. Four datasets (GSE23586, GSE16134, GSE10334, and GSE79705) pertaining to periodontitis were included in the analysis. A total of 48 representative crosstalk genes were identified by using the Boruta algorithm. Three TFs (FOS, MEF2C, and USF2) and several pathways (i.e., JAK-STAT, MAPK, NF-kappa B, and natural killer cell-mediated cytotoxicity) were identified as regulators of these crosstalk genes. Among these 48 crosstalk genes and the chronic periodontitis-related genes in DisGeNET, C4A, C4B, CXCL12, FCGR3A, IL1B, and MMP3 were shared and identified as the most pivotal candidate links between periodontitis and AD. Conclusions. Exploration of available transcriptomic datasets revealed C4A, C4B, CXCL12, FCGR3A, IL1B, and MMP3 as the top candidate molecular linkage genes between periodontitis and AD.
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外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
JCR分区：
出版当年[2019]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
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推荐引用方式(GB/T 7714)：
Jieqi Jin,Mengkai Guang,Anthony Chukwunonso Ogbuehi,et al.Shared Molecular Mechanisms between Alzheimer's Disease and Periodontitis Revealed by Transcriptomic Analysis[J].BIOMED RESEARCH INTERNATIONAL.2021,2021:doi:10.1155/2021/6633563.
APA：
Jieqi Jin,Mengkai Guang,Anthony Chukwunonso Ogbuehi,Simin Li,Kai Zhang...&Xiaofeng Huang.(2021).Shared Molecular Mechanisms between Alzheimer's Disease and Periodontitis Revealed by Transcriptomic Analysis.BIOMED RESEARCH INTERNATIONAL,2021,
MLA：
Jieqi Jin,et al."Shared Molecular Mechanisms between Alzheimer's Disease and Periodontitis Revealed by Transcriptomic Analysis".BIOMED RESEARCH INTERNATIONAL 2021.(2021)
