单位：[1]Department of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medical Sciences, Jiamusi, China[2]AnKang University, School of Medicine, Ankang, Shanxi Province 725000, China[3]Hainan University, Haikou, Hainan Province, China[4]First Affiliated Hospital of Xiamen University, Xiamen 361003, China[5]Beijing Friendship Hospital, Capital Medical University, Beijing 100000, China首都医科大学附属北京友谊医院[6]Inner Mongolia Medical University, Hohhot, Inner Mongolia, China[7]Jiamusi University, School of Clinical Medicine, Jiamusi, China
Introduction. Microribonucleic acids (miRNAs) have short (approximately 18 to 25) nucleotides and are evolutionarily conserved and endogenously expressed RNAs belonging to a family of noncoding RNA molecules. miRNA-373 regulates cell proliferation, migration, apoptosis, invasion, and repairing damaged DNA after hypoxia stress. Neonatal hypoxic-ischemic encephalopathy (HIE) refers to perinatal asphyxia caused by partial or complete hypoxia, reduced or suspended cerebral blood flow, and fetal or neonatal brain damage. We aim to investigate the relationship between miRNA-373 and HIF-1 alpha, between miRNA-373 MMP-9, and between miRNA-373 VEGF in the occurrence and development of HIE. Methods. Human (children) samples were divided into four groups (n=15 in each group) according to HIE severity. The patient group was divided into middle, moderate, and severe HIE groups. The control group included healthy children or children with nonneurological diseases. The expressions of miRNA-373, HIF-1 alpha, MMP-9, and VEGF were assayed in the serum samples. Results. Our study showed a strong relationship between miRNA-373 and HIF-1 alpha, between miRNA-373 and MMP-9, and between miRNA-373 and VEGF. The expression levels of miRNA-373, HIF-1 alpha, MMP-9, and VEGF in the HIE groups were much higher than those of the control group. Conclusion. The increased change in miRNA-373 expression has a certain diagnostic significance on neonatal HIE. In the occurrence and development of HIE, miRNA-373 is positively correlated with HIF-1 alpha, MMP-9, and VEGF.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30671803, 81273174]; Natural Science Foundation of Heilongjiang ProvinceNatural Science Foundation of Heilongjiang Province [LH2020H007]; Supporting Plan Project for Youth Academic Backbone of General Colleges and Universities of Heilongjiang Province [1253G058]; Basic Medical Discipline Team [JDXKTD-2019002]; Natural Science Major Project of Jiamusi University [Sz2011-007]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
JCR分区：
出版当年[2019]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Department of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medical Sciences, Jiamusi, China[2]AnKang University, School of Medicine, Ankang, Shanxi Province 725000, China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Chun-Yang,Al-Ward Hisham,Ngaffo Mekontso Francine,et al.Experimental Study on the Correlation between miRNA-373 and HIF-1 alpha, MMP-9, and VEGF in the Development of HIE[J].BIOMED RESEARCH INTERNATIONAL.2021,2021:doi:10.1155/2021/5553486.
APA：
Liu Chun-Yang,Al-Ward Hisham,Ngaffo Mekontso Francine,Liu Ning,Zeng Hui-Qin...&Xu Hui.(2021).Experimental Study on the Correlation between miRNA-373 and HIF-1 alpha, MMP-9, and VEGF in the Development of HIE.BIOMED RESEARCH INTERNATIONAL,2021,
MLA：
Liu Chun-Yang,et al."Experimental Study on the Correlation between miRNA-373 and HIF-1 alpha, MMP-9, and VEGF in the Development of HIE".BIOMED RESEARCH INTERNATIONAL 2021.(2021)
