单位：[1]Department of Interventional Ultrasound Medicine, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China[2]Department of Medical Ultrasound, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China[3]Department of Ultrasound, the First Affiliated Hospital of Dalian Medical University, Dalian, China大连医科大学附属第一医院[4]Department of Thyroid, Beijing Beicheng Chinese Medicine Hospital, Beijing, China[5]Department of Electrodiagnosis, the Affiliated Hospital to Changchun University of Traditional Chinese Medicine, Changchun, China[6]Department of Ultrasound, the First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou, China内蒙古科技大学包头医学院[7]Department of Breast and Thyroid Surgery, People’s Hospital of Xinjiang Uygur Autonomous, Wulumuqi, China[8]Department of Ultrasound, Wuhai People’s Hospital, Wuhai, China[9]Department of Interventional Ultrasound, Qinghai Provincial People’s Hospital, Xining, China[10]Department of Ultrasound, Mudanjiang Tumor Hospital, Mudanjiang, China[11]Special Inspection Section, Wendeng District People’s Hospital, Wendeng, China[12]First Department of Surgery, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang, China[13]Department of Ultrasound, Bayannur Hospital, Bayannur China[14]Department of Ultrasound, Laixi Municipal Hospital, Laixi, China
Background: Microwave ablation (MWA) and radiofrequency ablation (RFA) have recently attracted interest as minimally invasive treatment modalities for papillary thyroid carcinoma (PTC). However, the ablation outcomes of T1N0M0 PTC are not well characterized. Purpose: To evaluate the efficacy and safety of thermal ablation (MWA or RFA) of solitary T1N0M0 PTC in patients who were ineligible for (due to presence of comorbid cardiovascular disease, renal failure, other malignancy, etc) or who refused surgery. Materials and Methods: This was a retrospective multicenter study of 847 patients (660 women) who underwent thermal ablation for PTC (673 T1a, 174 T1b) between March 2015 and March 2020; of these patients, 645 underwent MWA and 202 underwent RFA. The mean age of patients was 46 years +/- 11 (standard deviation) (age range, 18-81 years); the mean follow-up time was 22 months +/- 13 (range, 6-60 months). Changes in tumor size and volume and the rates of technical success, tumor disappearance, disease progression, and complications were assessed. Results: The technical success rate was 100%. Relative to preablation measurements, the maximum diameter and volume of the ablation zone increased during the 1st month after ablation (P.001), whereas there was no difference by the 3rd month; subsequently, the tumors showed reduction in size at 6, 9, and 12 months (all P.001). Complete disappearance of tumors occurred in 68% of patients (577 of 847; 69% [466 of 673] in the T1a group vs 64% [111 of 174] in the T1b group; P.001). The postablation disease progression rate was 1.1% (nine of 847 patients; 0.9% [six of 673 patients] in the T1a group vs 1.7% [three of 174 patients] in the T1b group; P =.54). The overall complication rate was 3.4% (29 of 847 patients; 2.7% [18 of 673 patients] in the T1a group vs 6.3% [11 of 174 patients] in the T1b group; P =.02). Conclusion: This multicenter study provided evidence that thermal ablation is an effective and safe treatment option in selected -patients with solitary T1N0M0 papillary thyroid carcinoma. (C) RSNA, 2021
基金：
Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2017LH054]; Beijing Municipal Science and Technology CommissionBeijing Municipal Science & Technology Commission [Z181100001718135]
第一作者单位：[1]Department of Interventional Ultrasound Medicine, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Chaoyang District, Beijing 100029, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xiao-Jing Cao,Shu-Rong Wang,Ying Che,et al.Efficacy and Safety of Thermal Ablation for Treatment of Solitary T1N0M0 Papillary Thyroid Carcinoma: Multicenter Retrospective Study[J].RADIOLOGY.2021,300(1):209-216.doi:10.1148/radiol.2021202735.
APA：
Xiao-Jing Cao,Shu-Rong Wang,Ying Che,Juan Liu,Zhi-Bin Cong...&Ming-An Yu.(2021).Efficacy and Safety of Thermal Ablation for Treatment of Solitary T1N0M0 Papillary Thyroid Carcinoma: Multicenter Retrospective Study.RADIOLOGY,300,(1)
MLA：
Xiao-Jing Cao,et al."Efficacy and Safety of Thermal Ablation for Treatment of Solitary T1N0M0 Papillary Thyroid Carcinoma: Multicenter Retrospective Study".RADIOLOGY 300..1(2021):209-216
医学