单位：[1]Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[2]Department ofEndocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[3]Department of Radiology, Beijing TiantanHospital, Capital Medical University, Beijing, China[4]Department of Radiology, Beijing Friendship Hospital, Capital MedicalUniversity, Beijing, China医技科室影像中心放射科首都医科大学附属北京友谊医院[5]Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Beijing TiantanHospital, Capital Medical University, Beijing, China[6]China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[7]Collaborative Innovation Center for Brain Disorders,Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China
Objective: To explore the biochemical risk factors and imaging mechanisms of post fatigue after mild ischemic stroke among a Chinese population. Methods: Forty consecutive patients with mild ischemic stroke within onset of 14 +/- 2 days were enrolled between March and June 2018. The clinical information, scale data, biomarkers in peripheral venous blood, and imaging data during hospitalization and follow-up period were collected. Results: Patient age (range 34-78) was positively correlated with the prevalence of fatigue (p = 0.009). Both blood norepinephrine and serotonin levels during hospitalization were negatively correlated to the prevalence of post-stroke fatigue (model 1 p = 0.009 and model 2 P = 0.043, respectively). Infarct of right cerebral hemisphere is positively correlated with the occurrence of fatigue after mild ischemic stroke (p = 0.020). Compared to non-fatigue patients, amplitude of low-frequency fluctuation (ALFF) was lower in several areas of brain in stroke patients with fatigue, including the right orbital inferior frontal, right inner orbital frontal, right frontal, right triangular frontal inferior, right anterior and lateral cingulate, and right medial frontal gyruses. Analysis of the difference in functional connectivity between the fatigue and non-fatigue groups found no cluster. Conclusions: Frontal lobe-related neural pathways may play an essential role in the regulation of fatigue after mild ischemic stroke. Abnormal neural circuits may reduce the levels of neurotransmitters such as serotonin and norepinephrine and lead to post-stroke fatigue.
基金：
National Key Research & Development Program of China [2016YFC1307200]; Beijing Key Clinical Specialty; Beijing Brain Research [Z161100000216131]
第一作者单位：[1]Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[5]Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Beijing TiantanHospital, Capital Medical University, Beijing, China[6]China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital, Capital Medical University, Beijing, China[7]Collaborative Innovation Center for Brain Disorders,Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Zhang Xiaoxiao,Fang Hongjuan,Ma Ding,et al.Risk Factors and Imaging Mechanisms of Fatigue After Mild Ischemic Stroke: An Exploratory Study From a Single Chinese Center[J].FRONTIERS in NEUROLOGY.2021,12:doi:10.3389/fneur.2021.649021.
APA：
Zhang, Xiaoxiao,Fang, Hongjuan,Ma, Ding,Duan, Yunyun,Wang, Zhaozhao...&Wang, Chunxue.(2021).Risk Factors and Imaging Mechanisms of Fatigue After Mild Ischemic Stroke: An Exploratory Study From a Single Chinese Center.FRONTIERS in NEUROLOGY,12,
MLA：
Zhang, Xiaoxiao,et al."Risk Factors and Imaging Mechanisms of Fatigue After Mild Ischemic Stroke: An Exploratory Study From a Single Chinese Center".FRONTIERS in NEUROLOGY 12.(2021)
