单位：[a]Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Academy of Military Sciences, Beijing, 100071, China[b]School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China[c]Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院[d]Faculty of Psychology, Tianjin Normal University, Tianjin, 300387, China
Repeated early environmental deprivation is regarded as a typical paradigm to mimic the behavioral abnormalities and brain dysfunction that occur in psychiatric disorders. Previously, we reported that social isolation could disrupt prepulse inhibition (PPI) in Sprague-Dawley (SD) rats, producing the typical characteristics of a schizophrenia animal model. Based on further analysis of previous proteomic and transcriptomic data, a disrupted balance of glucose metabolism was found in the prefrontal cortex (PFC) of isolated rats. Subsequently, in the first experiment of this study, we investigated the effects of juvenile social isolation (postnatal days (PND) 21-34) on PPI and lactate levels in PND56 rats. Compared with the social rearing group, rats in the isolated rearing group showed disrupted PPI and increased lactate levels in the PFC. In the second experiment, at PND55, the model rats were acutely injected with a glycogen phosphorylase inhibitor (4-dideoxy-1,4-imino-darabinitol, DAB) or control saline in the bilateral PFC. Our data showed that acute DAB administration (50 pmol, 0.5 mu l) significantly improved the disrupted PPI and decreased the levels of oxidative phosphorylation (OXPHOS)related mRNAs as well as lactate. In summary, our results suggested that excess astrocytic lactate production was involved in the impairment of auditory sensory gating of isolated rats, which may contribute to the metabolic pathogenesis of schizophrenia.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31470988, 81471122]; China Post-doctoral Science FoundationChina Postdoctoral Science Foundation [2020M673689]
第一作者单位：[a]Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Academy of Military Sciences, Beijing, 100071, China[b]School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China
通讯作者：
通讯机构：[b]School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 100871, China[*1]School of Psychological and Cognitive Sciences, Peking University, 5 Yiheyuan Road, Beijing, 100871 China.
推荐引用方式(GB/T 7714)：
Lan Sun,Li Min,Man Li,et al.Juvenile social isolation leads to schizophrenia-like behaviors via excess lactate production by astrocytes[J].BRAIN RESEARCH BULLETIN.2021,174:240-249.doi:10.1016/j.brainresbull.2021.06.015.
APA：
Lan Sun,Li Min,Man Li&Feng Shao.(2021).Juvenile social isolation leads to schizophrenia-like behaviors via excess lactate production by astrocytes.BRAIN RESEARCH BULLETIN,174,
MLA：
Lan Sun,et al."Juvenile social isolation leads to schizophrenia-like behaviors via excess lactate production by astrocytes".BRAIN RESEARCH BULLETIN 174.(2021):240-249
