To analyze risk factors for the development of chronic gastritis in Conakry, Guinea, and to provide a basis for its prevention and control. A case group of patients who had a gastroscopy and a gastroscopy report at the Sino-German Friendship Hospital in Conakry from January 2019 to January 2020 was selected, while a control group of 107 patients with chronic lung diseases and other chronic diseases of the digestive system were selected. Factor logistic regression analysis of risk factors. The results show that chronic gastritis affects people aged 11 to 95 y, with the highest proportion of patients aged 18 to 30 y, 80 % of whom live in rural areas. The main risk factors for gastritis in the Conakry region of Guinea were a history of digestive problems, smoking for more than 10 y, fast eating, eating hot food at least once a week, and eating moldy food at least once a week. Protective factors against gastritis in Guinea Conakry are: regular diet. The adjusted population-attributable risk for the main risk factors for gastritis were a history of digestive problems 61.19 %, eating too fast 23.59 %, smoking for more than 10 y 26.60 %, eating hot food at least once a week 24.76 % and eating mouldy food at least once a week 6.87 %. The combined population-attributable risk for these factors was 79.07 %. A history of digestive disease, a smoking history of more than 10 y, fast food intake, hot food at least once a week and moldy food at least once a week were risk factors for the development of chronic gastritis in Guinea Conakry, and regular diet was a protective factor against the development of chronic gastritis in young and middle-aged patients in Guinea Conakry.