单位：[1]China Japan Friendship Hosp, Dept Neurol, Beijing 100029, Peoples R China[2]Beijing Normal Univ, McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning & IDG, Beijing 100875, Peoples R China[3]Beijing Normal Univ, BABRI Ctr, Beijing 100875, Peoples R China[4]China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China[5]Peking Univ, China Japan Friendship Sch Clin Med, Beijing 100029, Peoples R China
Background and Objective: Subjective memory impairment (SMI) is a preclinical stage prior to amnestic mild cognitive impairment (aMCI) along with the Alzheimer's disease (AD) continuum. We hypothesized that SMI patients had white matter (WM) network disruptions similar to those in aMCI patients. Methods: We used diffusion-tensor magnetic resonance imaging and graph theory to construct, analyze, and compare the WM networks among 20 normal controls (NC), 20 SMI patients, and 20 aMCI patients. Results: Compared with the NC group, the SMI group had significantly decreased global and local efficiency and an increased shortest path length. Moreover, similar to the aMCI group, the SMI group had lower nodal efficiency in regions located in the frontal and parietal lobes, limbic systems, and caudate nucleus compared to that of the NC group. Conclusion: Similar to aMCI patient, SMI patients exhibited WM network disruptions, and detection of these disruptions could facilitate the early detection of SMI.
基金：
National Key R&D Program of China [2016YFC1306301]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [D171100008217005]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [85138315]; National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [81625025]; State Key Program of National Natural Science of ChinaNational Natural Science Foundation of China (NSFC) [81430100]
第一作者单位：[1]China Japan Friendship Hosp, Dept Neurol, Beijing 100029, Peoples R China
通讯作者：
通讯机构：[1]China Japan Friendship Hosp, Dept Neurol, Beijing 100029, Peoples R China[2]Beijing Normal Univ, McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning & IDG, Beijing 100875, Peoples R China[3]Beijing Normal Univ, BABRI Ctr, Beijing 100875, Peoples R China[5]Peking Univ, China Japan Friendship Sch Clin Med, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Shao Wen,He Xuwen,Li Xin,et al.Disrupted White Matter Networks from Subjective Memory Impairment to Amnestic Mild Cognitive Impairment[J].CURRENT ALZHEIMER RESEARCH.2021,18(1):35-44.doi:10.2174/1567205018666210324115817.
APA：
Shao, Wen,He, Xuwen,Li, Xin,Tao, Wuhai,Zhang, Junying...&Peng, Dantao.(2021).Disrupted White Matter Networks from Subjective Memory Impairment to Amnestic Mild Cognitive Impairment.CURRENT ALZHEIMER RESEARCH,18,(1)
MLA：
Shao, Wen,et al."Disrupted White Matter Networks from Subjective Memory Impairment to Amnestic Mild Cognitive Impairment".CURRENT ALZHEIMER RESEARCH 18..1(2021):35-44
