单位：[1]CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences, Beijing 101400, China[2]School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China[3]Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China[4]Center of Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning 530004, China[5]Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China[6]Department of Dermatology, China-Japan Friendship Hospital, Beijing 100029, China[7]Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China[8]School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0245, USA
Traditional topical ointment applied on the skin surface has poor drug penetration due to the thickening of the stratum corneum for psoriasis. Microneedles (MNs) provide a desirable opportunity to promote drug penetration. However, the common MNs are difficult to meet the requirement of on-demand drug delivery. In this study, a smart electrical responsive MNs is fabricated by introducing conductive material of polypyrrole (PPy). Further, a self-powered controllable transdermal drug delivery system (sc-TDDS) based on piezoelectric nanogenerator (PENG) is developed. The sc-TDDS can control drug release by collecting and converting mechanical energy into electrical energy. The sc-TDDS can release 8.5 ng dexamethasone (Dex) subcutaneously per electrical stimulation. When treating psoriasis-like skin disease with sc-TDDS, the inflammatory skin returned to normal after 5 days, which is obviously better than treating with traditional Dex solution coating. This work provides a promising approach of on-demand transdermal drug release for various disease treatment scenarios.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [JQ20038]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61875015, 51873015, 81970994]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2020M680302]; Key-Area Research and Development Program of Guangdong Province [2018B030331001]; Joint Project of BRC-BC (Biomedical Translational Engineering Research Center of BUCT-CJFH) [XK2020-05]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities
第一作者单位：[1]CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences, Beijing 101400, China[2]School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
共同第一作者：
通讯作者：
通讯机构：[1]CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences, Beijing 101400, China[2]School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China[4]Center of Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning 530004, China
工程技术