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Role of tight junction-associated MARVEL protein marvelD3 in migration and epithelial-mesenchymal transition of hepatocellular carcinoma

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收录情况： ◇ SCIE

作者：

单位： [1]Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China [3]National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China [4]Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China [5]Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

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关键词： Hepatocellular carcinoma marvelD3 EMT migration NF-kappa B

摘要：

MarvelD3, a recently identified tight junction membrane protein, could be associated with hepatocellular carcinoma (HCC). We aimed to investigate the role of marvelD3 in Epithelial-Mesenchymal Transition (EMT) and migration of HCC and explore the underlying molecular mechanisms. First, we assessed marvlD3 expression in HCC and normal liver tissues and found loss of marvelD3 expression was significantly correlated with the occurrence and TNM stage of HCC. Second, we detected that marvelD3 was downregulated in HCC cells with transforming growth factor beta 1 and snail/slug-induced EMT. Finally, we analyzed expression of marvelD3 protein was significantly associated with EMT and the NF-kappa B signaling pathway. Our study demonstrated that MarvelD3 inhibited EMT and migration of HCC cells along with inhibiting NF-kappa B signaling pathway.

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中科院(CAS)分区：

出版当年[2020]版：

大类 | 3 区生物

小类 | 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区细胞生物学

JCR分区：

出版当年[2019]版：

Q2 CELL BIOLOGY

最新[2023]版：

Q3 CELL BIOLOGY

影响因子： 最新[2023版] 3.3 最新五年平均[2021-2025] 3.3 出版当年[2019版] 3.694 出版当年五年平均[2015-2019] 4.782 出版前一年[2018版] 3.296 出版后一年[2020版] 3.405

第一作者：

第一作者单位： [1]Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China [3]National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China

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通讯作者：

通讯机构： [1]Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China [2]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China [3]National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China [*1]Experimental Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China [*2]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China

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Role of tight junction-associated MARVEL protein marvelD3 in migration and epithelial-mesenchymal transition of hepatocellular carcinoma

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