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A Novel Pyroptosis-Related lncRNA Signature for Predicting the Prognosis of Skin Cutaneous Melanoma

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收录情况： ◇ SCIE

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单位： [1]Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China [2]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital,Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China [3]Department of General Surgery, Fuyang Hospital Affiliated to Anhui Medical University, Fuyang, Anhui, People’s Republic of China [4]Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China [5]College of Pharmacy, Jiangsu Ocean University, Lianyungang, Jiangsu, People’s Republic of China

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关键词： melanoma pyroptosis programmed cell death immunotherapy bioinformatics

摘要：

Purpose: To construct a prognosis model of melanoma based on pyroptosis related genes. Methods: Melanoma RNA-sequencing data was downloaded from TCGA. First, the lnRNAs related to pyroptosis were obtained through Pearson correlation analysis. Then, the prognosis model of pyroptosis related genes was constructed by Cox regression and Lasso regression. Melanoma patients were divided into high-risk and low-risk groups by risk score, and the differences in prognosis and immune microenvironment between the two groups were explored. Results: We found that the high-risk group had a significantly poorer prognosis, and different groups differed in immune infiltration, m6A methylation, and immune checkpoint. Conclusion: Our prognostic model can provide a reference for the study of pyroptosis in melanoma cells and provide a new idea for melanoma treatment.

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出版当年[2020]版：

大类 | 4 区医学

小类 | 3 区医学：内科

最新[2025]版：

大类 | 4 区医学

小类 | 3 区医学：内科

JCR分区：

出版当年[2019]版：

Q2 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q2 MEDICINE, GENERAL & INTERNAL

影响因子： 最新[2023版] 2.1 最新五年平均[2021-2025] 2.2 出版当年[2019版] 1.927 出版当年五年平均[2015-2019] 0 出版前一年[2018版] 0 出版后一年[2020版] 2.466

第一作者：

第一作者单位： [1]Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China

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通讯机构： [1]Department of Burn and Plastic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China [*1]Department of Burn and Plastic Surgery, The First Hospital Affiliated to Nanjing Medical University, Guangzhou Road 300, Nanjing, Jiangsu, 210029, People’s Republic of China

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