单位：[1]The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China,[2]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China,[3]Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China,[4]School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China,[5]Department of Ophthalmology, Traditional Chinese Medicine Hospital of Changping District, Beijing, China,[6]Department of Emergency, China-Japan Friendship Hospital, Beijing, China
Regulatory T cells (Tregs) represent a distinct subpopulation of CD4(+) T lymphocytes that promote immune tolerance and maintain immune system homeostasis. The dysfunction of Tregs is tightly associated with rheumatoid arthritis (RA). Although the complex pathogenic processes of RA remain unclear, studies on Tregs in RA have achieved substantial progress not only in fundamental research but also in clinical application. This review discusses the current knowledge of the characterizations, functions, and molecular mechanisms of Tregs in the pathogenesis of RA, and potential therapies for these disorders are also involved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82073677]
第一作者单位：[1]The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China,[2]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[2]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China,[6]Department of Emergency, China-Japan Friendship Hospital, Beijing, China
推荐引用方式(GB/T 7714)：
Xiaoya Li,Huihui Xu,Jing Huang,et al.Dysfunctions, Molecular Mechanisms, and Therapeutic Strategies of Regulatory T Cells in Rheumatoid Arthritis[J].FRONTIERS in PHARMACOLOGY.2021,12:doi:10.3389/fphar.2021.716081.
APA：
Xiaoya Li,Huihui Xu,Jing Huang,Dan Luo,Shuang Lv...&Cheng Xiao.(2021).Dysfunctions, Molecular Mechanisms, and Therapeutic Strategies of Regulatory T Cells in Rheumatoid Arthritis.FRONTIERS in PHARMACOLOGY,12,
MLA：
Xiaoya Li,et al."Dysfunctions, Molecular Mechanisms, and Therapeutic Strategies of Regulatory T Cells in Rheumatoid Arthritis".FRONTIERS in PHARMACOLOGY 12.(2021)
