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Autophagic activation of IRF-1 aggravates hepatic ischemia-reperfusion injury via JNK signaling

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单位: [1]Department of Hepatobiliary Surgery, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China [2]Department of Anesthesiology, Peking University Third Hospital, Beijing, China [3]Department of Obstetrics and Gynecology, JiaozuoWomen and Children Hospital, Jiaozuo, China [4]Department of Hepatobiliary Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China [5]Department of Liver Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China
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关键词: autophagy hepatic ischemia-reperfusion injury IRF-1 JNK

摘要:
Increasing evidence has accrued indicating that autophagy is associated with hepatic ischemia-reperfusion injury (IRI). This report demonstrates that interferon regulatory factor-1 (IRF-1) was upregulated in response to hepatic IRI and was associated with autophagic activation. As a result of these processes, there is an aggravation of liver damage, effects that can be offset by IRF-1 depletion. In addition, these effects of IRF-1 are associated with JNK pathway activation followed by increases in Beclin1 protein levels. This JNK-induced autophagic cell death then leads to cell failure, and plays an important role in liver function damage. We conclude that IRF-1 activates autophagy through JNK-mediated autophagy. Accordingly, these findings indicating that the IRF-1/JNK pathway activates autophagy to exacerbate liver IRI in this mouse model may provide new insights into novel protective therapies for hepatic IRI.

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大类 | 1 区 医学
小类 | 1 区 医学:研究与实验
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Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子: 最新[2024版] 最新五年平均[2021-2025] 出版当年[2019版] 出版当年五年平均[2015-2019] 出版前一年[2018版]

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第一作者单位: [1]Department of Hepatobiliary Surgery, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China [*1]Department of Hepatobiliary Surgery, FirstAffiliated Hospital ofXinxiang Medical University,Xinxiang,Henan Province 453100, China.
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通讯机构: [1]Department of Hepatobiliary Surgery, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China [4]Department of Hepatobiliary Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China [5]Department of Liver Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China [*1]Department of Hepatobiliary Surgery, FirstAffiliated Hospital ofXinxiang Medical University,Xinxiang,Henan Province 453100, China. [*2]Department ofHepatobiliary Surgery, FirstAffiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450000, China. [*3]Department of Liver Transplantation, Beijing FriendshipHospital, CapitalMedical University,Beijing 100050,China.
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