单位:[1]Department of Hepatobiliary Surgery, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China[2]Department of Anesthesiology, Peking University Third Hospital, Beijing, China[3]Department of Obstetrics and Gynecology, JiaozuoWomen and Children Hospital, Jiaozuo, China[4]Department of Hepatobiliary Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[5]Department of Liver Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室国家中心普外分中心普外四科(肝脏移植外科)首都医科大学附属北京友谊医院
Increasing evidence has accrued indicating that autophagy is associated with hepatic ischemia-reperfusion injury (IRI). This report demonstrates that interferon regulatory factor-1 (IRF-1) was upregulated in response to hepatic IRI and was associated with autophagic activation. As a result of these processes, there is an aggravation of liver damage, effects that can be offset by IRF-1 depletion. In addition, these effects of IRF-1 are associated with JNK pathway activation followed by increases in Beclin1 protein levels. This JNK-induced autophagic cell death then leads to cell failure, and plays an important role in liver function damage. We conclude that IRF-1 activates autophagy through JNK-mediated autophagy. Accordingly, these findings indicating that the IRF-1/JNK pathway activates autophagy to exacerbate liver IRI in this mouse model may provide new insights into novel protective therapies for hepatic IRI.
基金:
NationalNatural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81700556]; Henan Medical Science andTechnology Program [SB201902007]; Colleges and Universities in Henan Province [20A320077]
第一作者单位:[1]Department of Hepatobiliary Surgery, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China[*1]Department of Hepatobiliary Surgery, FirstAffiliated Hospital ofXinxiang Medical University,Xinxiang,Henan Province 453100, China.
共同第一作者:
通讯作者:
通讯机构:[1]Department of Hepatobiliary Surgery, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China[4]Department of Hepatobiliary Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China[5]Department of Liver Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Department of Hepatobiliary Surgery, FirstAffiliated Hospital ofXinxiang Medical University,Xinxiang,Henan Province 453100, China.[*2]Department ofHepatobiliary Surgery, FirstAffiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450000, China.[*3]Department of Liver Transplantation, Beijing FriendshipHospital, CapitalMedical University,Beijing 100050,China.
推荐引用方式(GB/T 7714):
Shipeng Li,Jindan He,Hongwei Xu,et al.Autophagic activation of IRF-1 aggravates hepatic ischemia-reperfusion injury via JNK signaling[J].MEDCOMM.2021,2(1):91-100.doi:10.1002/mco2.58.
APA:
Shipeng Li,Jindan He,Hongwei Xu,Jiaxing Yang,Yutian Luo...&Haiming Zhang.(2021).Autophagic activation of IRF-1 aggravates hepatic ischemia-reperfusion injury via JNK signaling.MEDCOMM,2,(1)
MLA:
Shipeng Li,et al."Autophagic activation of IRF-1 aggravates hepatic ischemia-reperfusion injury via JNK signaling".MEDCOMM 2..1(2021):91-100