单位：[a]Department of Medical Oncology, Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China[b]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Disease, Beijing, China
Introduction Drug-induced pulmonary toxicity (DIPT) associated with breast cancer (BC) therapy has been a major concern in recent times. DIPT may not be attributed to a single type of therapy because of the concomitant use of other anticancer drugs or along with radiotherapy, which is an independent risk factor for pulmonary toxicity. Areas covered In this systematic literature review, we evaluated the probable cause and prevalence of DIPT in various systemic therapies used in BC treatment. A literature search was conducted in PubMed, Embase and Cochrane database, up to October 2020. Clinical studies reporting DIPT and related clinical manifestations due to systemic therapy in BC treatment were included. A total of 1749 articles were retrieved, and 193 articles were included. Expert opinion : The leading cause of DIPT among patients with BC was targeted therapy followed by chemotherapy containing regimens. A total of 17 studies reported 35 deaths (15 deaths in chemotherapy) due to DIPT. Physicians must take extra precaution while prescribing systemic therapy known to be associated with DIPT and need to be familiar with early diagnosis of DIPT in order to avoid respiratory-related complications during treatment in BC patients.
第一作者单位：[a]Department of Medical Oncology, Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[b]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Disease, Beijing, China[*1]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Center for Respiratory Medicine, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Disease, Beijing, China
推荐引用方式(GB/T 7714)：
Shanshan Chen,Yanhong Ren,Huaping Dai,et al.Drug-induced pulmonary toxicity in breast cancer patients treated with systemic therapy: a systematic literature review[J].EXPERT REVIEW of ANTICANCER THERAPY.2021,21(12):1399-1410.doi:10.1080/14737140.2021.1996229.
APA：
Shanshan Chen,Yanhong Ren,Huaping Dai,Yiqun Li,Bo Lan&Fei Ma.(2021).Drug-induced pulmonary toxicity in breast cancer patients treated with systemic therapy: a systematic literature review.EXPERT REVIEW of ANTICANCER THERAPY,21,(12)
MLA：
Shanshan Chen,et al."Drug-induced pulmonary toxicity in breast cancer patients treated with systemic therapy: a systematic literature review".EXPERT REVIEW of ANTICANCER THERAPY 21..12(2021):1399-1410
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