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Progranulin correlated with rapid progressive interstitial lung disease in dermatomyositis with anti-melanoma differentiation-associated gene 5 antibody

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单位： [1]Department of Rheumatology, China-Japan Friendship Hospital, No.2 Yinghua East st, Chaoyang District, Beijing, China [2]Department of Radiology, China-Japan Friendship Hospital, Beijing, China

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关键词： Dermatomyositis Melanoma differentiation-associated gene 5 Rapidly progressive interstitial lung disease Progranulin

摘要：

Objectives This study aimed to detect the expression of progranulin (PGRN) and elucidate associations with clinical features in dermatomyositis (DM) patients with anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody. Methods We enrolled 40 DM patients with anti-MDA5 antibody, 20 patients with antisynthetase syndrome (ASS; disease control), and 20 healthy individuals (healthy control, HC). The clinical features of patients with anti-MDA5 antibody and anti-histidyl-tRNA antibody were collected. The level of PGRN in the serum was tested by ELISA. Results The PGRN levels in DM patients with anti-MDA5 antibody (166.74 +/- 97.95 ng/ml) were significantly higher than those in patients with ASS (82.66 +/- 40.50 ng/ml; p < 0.001) and in HC (42.34 +/- 18.69 ng/ml; p < 0.001). Patients with rapid progressive interstitial lung disease (RP-ILD) in DM with anti-MDA5 antibody (213.57 +/- 114.05 ng/ml) had higher levels of PGRN than those without RP-ILD (135.51 +/- 72.41 ng/ml; p = 0.012). ROC analysis showed an AUC value at 0.715 (95% CI, 0.541-0.888) for diagnosis of RP-ILD in DM patients with anti-MDA5 antibody. The expression of PGRN was positively correlated with the levels of ALT, AST, CK, LDH and ferritin (all p < 0.05). Conclusions Our results indicated PGRN had great potential as a valuable serum marker of RP-ILD in DM with anti-MDA5 antibody.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 4 区风湿病学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区风湿病学

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出版当年[2020]版：

Q3 RHEUMATOLOGY

最新[2023]版：

Q2 RHEUMATOLOGY

影响因子： 最新[2023版] 2.9 最新五年平均[2021-2025] 2.8 出版当年[2020版] 2.98 出版当年五年平均[2016-2020] 2.948 出版前一年[2019版] 2.394 出版后一年[2021版] 3.65

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第一作者单位： [1]Department of Rheumatology, China-Japan Friendship Hospital, No.2 Yinghua East st, Chaoyang District, Beijing, China

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