单位：[1]Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.[2]Department of Endocrinology, Beijing Friendship Hospital Pinggu Campus, Capital Medical University, Beijing, China.临床科室内分泌科内分泌科首都医科大学附属北京友谊医院[3]Nutrition department, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Xicheng District, Beijing, China.
Background The comparatively low 25 hydroxyvitamin D [25(OH)D] levels have been reported in patients with metabolic syndrome (MetS). Herein we investigated the cross-sectional and longitudinal relationships between serum 25(OH)D levels and MetS risk profile in northern middle-aged Chinese subjects without vitamin D supplementation. Methods A cohort of 211 participants including 151 MetS patients and 60 controls at 20-69 years of age were enrolled from suburban Beijing, China. The recruited MetS patients were subjected to diet and exercise counselling for 1-year. All subjects at baseline and MetS patients after intervention underwent clinical evaluations. Results Serum 25(OH)D levels were significantly decreased in MetS patients. 25(OH)D levels were inversely related to MetS score, fasting blood glucose (FBG) and triglyceride-glucose index (TyG) after adjusting for cofounders (all P < 0.05). Participants in the lowest tertile of 25(OH)D levels had increased odds for MetS (P = 0.045), elevated FBG (P = 0.004) in all subjects, and one MetS score gain in MetS patients (P = 0.005). Longitudinally, the metabolic statuses as well as 25(OH)D levels of MetS patients were significantly improved (all P < 0.05), and the increase of 25(OH)D levels were inversely related to MetS scores, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), FBG, and TyG, while positively related to high-density lipoprotein cholesterol (HDL-C) after adjusting for confounders. Conclusions 25(OH)D levels were significantly decreased in MetS patients, and it was negatively associated with metabolic dysfunctions at baseline and 1-year after. Metabolic aberrations of MetS patients were significantly ameliorated with 1-year follow-up counselling accompanying by notably elevated 25(OH)D levels.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7182130, 7082079]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81370898, 30771026, 30540036]; China Diabetes Young Scientific Talent Research Project [2020-N-01-10]; National Key Technology Research and Development Program of China during the "11th Five-Year Plan" from the Ministry of Science and TechnologyNational Key Technology R&D Program [2006BAI01A01]; National Key Program of Clinical Science [WBYZ2011-873]; PUMCH Foundation [pumch-2013-020]; Innovation fund for postgraduate students of Peking Union Medical College [2019-1002-26]
第一作者单位：[1]Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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推荐引用方式(GB/T 7714)：
Xu Hanyuan,Han Guiyan,Wang Linjie,et al.25-hydroxyvitamin D levels are inversely related to metabolic syndrome risk profile in northern Chinese subjects without vitamin D supplementation[J].DIABETOLOGY & METABOLIC SYNDROME.2022,14(1):doi:10.1186/s13098-022-00793-1.
APA：
Xu Hanyuan,Han Guiyan,Wang Linjie,Ding Huihua,Wang Chunyan...&Xing Xiaoping.(2022).25-hydroxyvitamin D levels are inversely related to metabolic syndrome risk profile in northern Chinese subjects without vitamin D supplementation.DIABETOLOGY & METABOLIC SYNDROME,14,(1)
MLA：
Xu Hanyuan,et al."25-hydroxyvitamin D levels are inversely related to metabolic syndrome risk profile in northern Chinese subjects without vitamin D supplementation".DIABETOLOGY & METABOLIC SYNDROME 14..1(2022)
