单位：[1]Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 South Gongti Road, Chao Yang District, Beijing 100020, China.北京朝阳医院[2]Department of Stomatology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China.[3]Department of Stomatology, The Third People’s Hospital of Datong City, Datong 037008, China.[4]Department of Endocrinology, Beijing Friendship Hospital Pinggu Campus, Capital Medical University, No.59 Xinping North Road, Pinggu District, Beijing 101200, China.临床科室内分泌科内分泌科首都医科大学附属北京友谊医院
Background To investigate the difference in the structural composition of salivary flora between chronic periodontitis patients with and without diabetic nephropathy (DN). Methods Thirty salivary samples of 15 chronic periodontitis patients with DN (DN group) and 15 chronic periodontitis patients with diabetes but without DN (DM group) were subjected to pyrosequencing of polymerase chain reaction-amplified 16 s ribosomal RNA genes. After diversity testing, the differential flora were analyzed. The sequencing results were compared with GenBank database to determine the type of differential flora using species composition analysis, hierarchical cluster analysis, principal co-ordinate analysis, and species difference analysis. Results There were significant between-group differences with respect to Gemella, Selenomonas spp, Lactobacillales_unclassified, Bacteria-unclassified and Abiotrophia (p < 0.05). Compared with DM group, the relative abundance of Selenomonas spp. in DN group was significantly higher; the area under the receiver operating characteristic curve of Selenomonas spp. was 0.713 (P < 0.05). Multi-level biological identification and feature maps indicated that Selenomonas spp. might be used as a potential biomarker for DN patients. On binary logistic regression analysis, increase of Selenomonas spp. was related with DN. Conclusions We found significant between-group differences in the structural composition of oral flora. The increase in the relative abundance of Selenomonas spp. may be associated with DN in patients with chronic periodontitis.
第一作者单位：[1]Department of Stomatology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 South Gongti Road, Chao Yang District, Beijing 100020, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Dongxue,Liu Wenyan,Peng Li,et al.Difference in oral microbial composition between chronic periodontitis patients with and without diabetic nephropathy[J].BMC ORAL HEALTH.2022,22(1):doi:10.1186/s12903-021-01985-3.
APA：
Zhang Dongxue,Liu Wenyan,Peng Li,Wang Haiyan,Lin Mei...&Wang Zuomin.(2022).Difference in oral microbial composition between chronic periodontitis patients with and without diabetic nephropathy.BMC ORAL HEALTH,22,(1)
MLA：
Zhang Dongxue,et al."Difference in oral microbial composition between chronic periodontitis patients with and without diabetic nephropathy".BMC ORAL HEALTH 22..1(2022)
