单位:[1]Department of Respiratory Medicine, The First Hospital of Jilin University, Jilin University, Changchun, China[2]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital[3]National Center for Respiratory Medicine[4]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences[5]National Clinical Research Center for Respiratory Diseases, Beijing, China[6]Chinese Academy of Medical Sciences, Graduate School of Peking Union Medical College, Beijing, China[7]Department of Radiology, China-Japan Friendship Hospital, Beijing, China
Introduction Lung transplantation has proven to be an effective treatment option for end-stage lung disease. However, early and late complications following transplantation remain significant causes of high mortality. Objectives In this review, we focus on the time of onset in primary graft dysfunction and rejection complications, as well as emphasize the role of imaging manifestations and pathological features in early diagnosis, thus assisting clinicians in the early detection and treatment of posttransplant complications and improving patient quality of life and survival. Data source We searched electronic databases such as PubMed, Web of Science, and EMBASE. We used the following search terms: lung transplantation complications, primary graft dysfunction, acute rejection, chronic lung allograft dysfunction, radiological findings, and diagnosis and treatment. Conclusion Primary graft dysfunction, surgical complications, immune rejection, infections, and neoplasms represent major posttransplant complications. As the main posttransplant survival limitation, chronic lung allograft dysfunction has a characteristic imaging presentation; nevertheless, the clinical and imaging manifestations are often complex and overlap, so it is essential to understand the temporal evolution of these complications to narrow the differential diagnosis for early treatment to improve prognosis.
基金:
Chinese Academy of Medical Sciences, Science and Technology Innovation in Medicine and Health Project (Major Collaborative Innovation Project) [2018-I2M-1-0001]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT320021]
第一作者单位:[1]Department of Respiratory Medicine, The First Hospital of Jilin University, Jilin University, Changchun, China[2]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital[3]National Center for Respiratory Medicine
通讯作者:
通讯机构:[1]Department of Respiratory Medicine, The First Hospital of Jilin University, Jilin University, Changchun, China[2]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital[3]National Center for Respiratory Medicine[4]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences[*1]Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China.[*2]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital: National Center for Respiratory Medicine: Institute of Respiratory Medicine, Chinese Academy of Medical Sciences: National Clinical Research Center for Respiratory Diseases, Beijing 100029, China[*3]Chinese Academy of Medical Sciences, Graduate School of Peking Union Medical College, Beijing, China, and Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, 130021, China
推荐引用方式(GB/T 7714):
Sun Haishuang,Deng Mei,Chen Wenhui,et al.Graft dysfunction and rejection of lung transplant, a review on diagnosis and management[J].CLINICAL RESPIRATORY JOURNAL.2022,16(1):5-12.doi:10.1111/crj.13471.
APA:
Sun, Haishuang,Deng, Mei,Chen, Wenhui,Liu, Min,Dai, Huaping&Wang, Chen.(2022).Graft dysfunction and rejection of lung transplant, a review on diagnosis and management.CLINICAL RESPIRATORY JOURNAL,16,(1)
MLA:
Sun, Haishuang,et al."Graft dysfunction and rejection of lung transplant, a review on diagnosis and management".CLINICAL RESPIRATORY JOURNAL 16..1(2022):5-12