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Graft dysfunction and rejection of lung transplant, a review on diagnosis and management

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单位: [1]Department of Respiratory Medicine, The First Hospital of Jilin University, Jilin University, Changchun, China [2]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital [3]National Center for Respiratory Medicine [4]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences [5]National Clinical Research Center for Respiratory Diseases, Beijing, China [6]Chinese Academy of Medical Sciences, Graduate School of Peking Union Medical College, Beijing, China [7]Department of Radiology, China-Japan Friendship Hospital, Beijing, China
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关键词: chronic lung allograft dysfunction lung transplantation complications primary graft dysfunction radiological findings treatment

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Introduction Lung transplantation has proven to be an effective treatment option for end-stage lung disease. However, early and late complications following transplantation remain significant causes of high mortality. Objectives In this review, we focus on the time of onset in primary graft dysfunction and rejection complications, as well as emphasize the role of imaging manifestations and pathological features in early diagnosis, thus assisting clinicians in the early detection and treatment of posttransplant complications and improving patient quality of life and survival. Data source We searched electronic databases such as PubMed, Web of Science, and EMBASE. We used the following search terms: lung transplantation complications, primary graft dysfunction, acute rejection, chronic lung allograft dysfunction, radiological findings, and diagnosis and treatment. Conclusion Primary graft dysfunction, surgical complications, immune rejection, infections, and neoplasms represent major posttransplant complications. As the main posttransplant survival limitation, chronic lung allograft dysfunction has a characteristic imaging presentation; nevertheless, the clinical and imaging manifestations are often complex and overlap, so it is essential to understand the temporal evolution of these complications to narrow the differential diagnosis for early treatment to improve prognosis.

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出版当年[2021]版:
大类 | 4 区 医学
小类 | 4 区 呼吸系统
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 呼吸系统
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出版当年[2020]版:
Q3 RESPIRATORY SYSTEM
最新[2023]版:
Q3 RESPIRATORY SYSTEM

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第一作者单位: [1]Department of Respiratory Medicine, The First Hospital of Jilin University, Jilin University, Changchun, China [2]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital [3]National Center for Respiratory Medicine
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通讯机构: [1]Department of Respiratory Medicine, The First Hospital of Jilin University, Jilin University, Changchun, China [2]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital [3]National Center for Respiratory Medicine [4]Institute of Respiratory Medicine, Chinese Academy of Medical Sciences [*1]Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China. [*2]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital: National Center for Respiratory Medicine: Institute of Respiratory Medicine, Chinese Academy of Medical Sciences: National Clinical Research Center for Respiratory Diseases, Beijing 100029, China [*3]Chinese Academy of Medical Sciences, Graduate School of Peking Union Medical College, Beijing, China, and Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, 130021, China
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