单位：[1]Beijing Key Lab of CryoBiomedical Engineering and Key Lab of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China[2]Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China[3]Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China[4]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China[5]School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China[6]Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China
Liquid metals (LMs) not only retain the basic properties of metallic biomaterials, such as high thermal conductivity and high electrical conductivity, but also possess flexibility, flowability, deformability, plasticity, good adhesion, and so on. Therefore, they open many possibilities of extending soft metals into biomedical sciences including biomedical imaging. One of the special properties of LMs is that they can provide a controllable material system in which the electrical, thermal, mechanical, and chemical properties can be controlled on a large scale. This paper reviews the preparation and characteristics of LM-based biomaterials classified into four categories: LM micro/nanoparticles, surface modified LM droplets, LM composites with inorganic substances, and LM composites with organic polymers. Besides, considering the most important requirement for biomaterials is biocompatibility, the paper also analyzes the toxicity results of various LM biomaterials when used in the biomedical area, from different levels including body weight measurement, histology evaluation, and blood biochemistry tests. Next, the applications of LMs in X-ray, CT, MRI, photoacoustic imaging, and molecular imaging are introduced in detail. And finally, the challenges and opportunities of their application in medical imaging are also discussed.
基金：
Beijing Science and Technology Planning Project [Z191100007619021]; National Natural Science Foundation of China (NSFC) [81971585]; National Key Research and Development Program of China [2020YFC2003903, 2020YFC2007301]
第一作者单位：[1]Beijing Key Lab of CryoBiomedical Engineering and Key Lab of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China[2]Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, China[3]Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Key Lab of CryoBiomedical Engineering and Key Lab of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China[5]School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式(GB/T 7714)：
Gao Wenwen,Wang Yige,Wang Qian,et al.Liquid metal biomaterials for biomedical imaging[J].JOURNAL of MATERIALS CHEMISTRY B.2022,10(6):829-842.doi:10.1039/d1tb02399c.
APA：
Gao, Wenwen,Wang, Yige,Wang, Qian,Ma, Guolin&Liu, Jing.(2022).Liquid metal biomaterials for biomedical imaging.JOURNAL of MATERIALS CHEMISTRY B,10,(6)
MLA：
Gao, Wenwen,et al."Liquid metal biomaterials for biomedical imaging".JOURNAL of MATERIALS CHEMISTRY B 10..6(2022):829-842
