Unmet Needs of Glycaemic Control and Risk Factors of Residual Hyperglycaemia in a Chinese Population with Type 2 Diabetes Initiating Basal Insulin: A Post Hoc Analysis of the FPG GOAL Study
单位:[1]China Japan Friendship Hosp, Dept Endocrinol, Beijing 100029, Peoples R China[2]Sanofi Med, Shanghai, Peoples R China[3]Sanofi Real World Evidence, Shanghai, Peoples R China
Introduction To aim of this analysis was to investigate the extent and evaluate risk factors of residual hyperglycaemia in Chinese individuals with type 2 diabetes (T2D) initiating basal insulin. Methods FPG GOAL was a 24-week, open-label, treat-to-target randomised controlled trial in Chinese individuals with T2D inadequately controlled with oral anti-hyperglycaemic drugs initiating treatment with basal insulin. This analysis categorised participants into the following glycaemic control categories: hyperglycaemia [glycated haemoglobin (HbA1c) >= 53 mmol/mol (>= 7%), fasting plasma glucose (FPG) >= 7.0 mmol/L], residual hyperglycaemia [HbA1c >= 53 mmol/mol (>= 7%), FPG < 7.0 mmol/L], discordant [HbA1c < 53 mmol/mol (< 7%), FPG >= 7.0 mmol/L] and at target [HbA1c < 53 mmol/mol (< 7%), FPG < 7.0 mmol/L]. The proportion of participants in each glycaemic control category was assessed at weeks 12 and 24. Multivariable regression analyses were conducted to evaluate risk factors for residual hyperglycaemia. Results Of the 914 participants included, 22.1% had residual hyperglycaemia, 31.9% had hyperglycaemia, 11.1% were discordant and 29.3% were at target at week 24. More participants who were randomised to a fasting blood glucose (FBG) target of > 3.9 to <= 5.6 mmol/L had residual hyperglycaemia compared with participants randomised to a FBG target of > 3.9 to <= 6.1 mmol/L or > 3.9 to <= 7.0 mmol/L. Multivariable analysis indicated that higher HbA1c and lower FPG levels at baseline were associated with greater proportion of residual hyperglycaemia. Conclusion Some Chinese individuals with T2D may have residual hyperglycaemia 3-6 months after initiating basal insulin treatment and require further intensified treatment. Higher HbA1c and lower FPG levels could be risk factors for residual hyperglycaemia.
基金:
Sanofi
语种:
外文
WOS:
中科院(CAS)分区:
出版当年[2021]版:
大类|3 区医学
小类|3 区药学4 区医学:研究与实验
最新[2025]版:
大类|3 区医学
小类|2 区药学3 区医学:研究与实验
JCR分区:
出版当年[2020]版:
Q2PHARMACOLOGY & PHARMACYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2PHARMACOLOGY & PHARMACY
第一作者单位:[1]China Japan Friendship Hosp, Dept Endocrinol, Beijing 100029, Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Wang Xin,Wu Guangyu,Shen Dan,et al.Unmet Needs of Glycaemic Control and Risk Factors of Residual Hyperglycaemia in a Chinese Population with Type 2 Diabetes Initiating Basal Insulin: A Post Hoc Analysis of the FPG GOAL Study[J].ADVANCES in THERAPY.2022,39(6):2820-2830.doi:10.1007/s12325-022-02128-y.
APA:
Wang, Xin,Wu, Guangyu,Shen, Dan,Zhang, Xia&Yang, Wenying.(2022).Unmet Needs of Glycaemic Control and Risk Factors of Residual Hyperglycaemia in a Chinese Population with Type 2 Diabetes Initiating Basal Insulin: A Post Hoc Analysis of the FPG GOAL Study.ADVANCES in THERAPY,39,(6)
MLA:
Wang, Xin,et al."Unmet Needs of Glycaemic Control and Risk Factors of Residual Hyperglycaemia in a Chinese Population with Type 2 Diabetes Initiating Basal Insulin: A Post Hoc Analysis of the FPG GOAL Study".ADVANCES in THERAPY 39..6(2022):2820-2830