Retrograde Intrarenal Surgery (RIRS) is one of minimally invasive procedures for pediatric upper urinary stones. However, a RIRS predictive system for children to evaluate postoperative stone free rate (SFR) is still unavailable.The aim of this study is to validate the efficacy and reliability of different RIRS scoring systems for children.We collected clinical data of 137 pediatric patients treated with RIRS in our center between 2014 and 2021. All the predictors were acquired by preoperative non-contrast CT or CT urography. Receiver Operative Curve (ROC) and Area Under Curve (AUC) were showed to compare the predictive power of different models.A total of 162 RIRS procedures were performed for these 137 pediatric patients. Median surgical duration, irrigation volume and hospitalization were 30 (20, 40) min, 500 (300, 1000) ml and 6 (4, 7) days, respectively. Overall SFR and complication rate was 79.6% (129/162) and 29.2% (40/137), respectively. Significant difference was detected between non-stone free group and stone free group in terms of stone complexity (p < 0.001), cumulative stone sizes [2.3 (2.0, 3.5) cm vs. 1.5 (1.0, 2.0) cm, p < 0.001], RUS groups (p < 0.001), S-ReSC groups (p < 0.001) and RIRS nomogram score [10 (8, 12) vs. 23 (18, 25), p < 0.001]. Among them, RIRS nomogram presented with the maximum AUC values in comparison with the other two systems (RUS: 0.944 vs. 0.874, p = 0.001; S-ReSC: 0.944 vs. 0.808, p < 0.001).We reported the largest sample size of pediatric patients treated with RIRS in our center. Similar with previous studies, RIRS is an efficacious and safe option for pediatric patients. RIRS nomogram showed the best predictive outcome due to the inclusion of multiple parameters, but an innovative predictive system based on pediatric clinical data is warranted in the future.Among the three scoring systems, RIRS nomogram showed the most optimal predictive power of postoperative SFR for pediatric patients.Copyright © 2022 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.