The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study
单位：[1]Rheumatology, Guang'anmen Hospital China Academy of Chinese Medical Sciences, Beijing 100053, China.[2]Rheumatology, University of Chinese Medicine, Hefei 230038, China.[3]3 Rheumatology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Suzhou 215002, China.[4]Rheumatology, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.[5]Rheumatology, The Southwest Hospital of AMU, Chongqing 400038, China.[6]Rheumatology, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200052, China.[7]Rheumatology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China.[8]Rheumatology, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shandong 250011, China.[9]Rheumatology, Peking Union Medical College Hospital, Beijing 100730, China.[10]Rheumatology, Bethune International Peace Hospital, Shijiazhuang 050000, China.[11]Rheumatology, Peking University People's Hospital, Beijing 100044, China.[12]Rheumatology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510220, China.广东省中医院[13]Rheumatology, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.[14]Rheumatology, The Fifth Hospital of Xi'an, Xi'an, China.[15]Rheumatology, Xiyuan Hospital China Academy of Chinese Medical Sciences, Beijing, China.[16]Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China.[17]Rheumatology, The Second Affiliated Hospital of Zhejiang University of Chinese Medicine, Hangzhou 310005, China.
Traditional Chinese medicine (TCM) has been used successfully to treat rheumatoid arthritis (RA). QingreHuoxue treatment (QingreHuoxue decoction [QRHXD]/QingreHuoxue external preparation [QRHXEP]) is a Chinese medicine treatment for RA. To date, very few studies have compared the long-term effects of QRHXD with those of conventional disease-modifying antirheumatic drugs on RA disease activity and radiological progression. QRHXD delayed the radiological progression and showed long-term clinical efficacy of RA. In clinical experiments, the clinical evidence of delaying the radiological progression of RA patients was obtained. A portion of the patients who participated in the "Traditional Chinese Medicine QingreHuoxue Treatment vs. the Combination of Methotrexate and Hydroxychloroquine for Active Rheumatoid Arthritis" study were followed up for 52 weeks, and intention-to-treat (ITT) and compliance protocol (PP) analyses were used to collect and compare the clinical indicators and imaging data between baseline and week 52. Two radiologists who were blind to treatment scored the images independently. Of the 468 subjects, 141 completed the 52-week follow-up. There were no significant differences among the three groups: the traditional Chinese medicine comprehensive treatment group, the Western medicine treatment group, and the integrated traditional Chinese and Western medicine treatment group. There were no differences in the total Sharp score, joint space stenosis score, and joint erosion score at baseline or 52 weeks. In the comparison of the estimated annual radiographic progression (EARP) and the actual annual Sharp total score changes among the three groups, the actual changes were much lower than the EARP at baseline. The radiological progress in all three groups was well controlled. Results of the ITT and PP data sets showed that the disease activity score 28 level of the three groups at 52 weeks was significantly lower than that at baseline. During the 52-week treatment period, the clearance of heat and promotion of blood circulation controlled disease activity and delayed the radiological progress of active RA.
基金：
National Key Research and Development Program [2018YFC1705202]; Chinese National Science and Technology Support Program [2013BAI02B06]
第一作者单位：[1]Rheumatology, Guang'anmen Hospital China Academy of Chinese Medical Sciences, Beijing 100053, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Rouman,Tang Xiao-Po,Wang Jian,et al.The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study[J].EVIDENCE-BASED COMPLEMENTARY and ALTERNATIVE MEDICINE.2022,2022:doi:10.1155/2022/5808400.
APA：
Zhang Rouman,Tang Xiao-Po,Wang Jian,Liu Wei-Xiang,Liu Jian...&Gong Xun.(2022).The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study.EVIDENCE-BASED COMPLEMENTARY and ALTERNATIVE MEDICINE,2022,
MLA：
Zhang Rouman,et al."The Impact of Traditional Chinese Medicine QingreHuoxue Treatment and the Combination of Methotrexate and Hydroxychloroquine on the Radiological Progression of Active Rheumatoid Arthritis: A 52-Week Follow-Up of a Randomized Controlled Clinical Study".EVIDENCE-BASED COMPLEMENTARY and ALTERNATIVE MEDICINE 2022.(2022)
