高级检索
当前位置: 首页 > 详情页

Effect and Safety of Helicobacter pylori Eradication Treatment Based on Molecular Pathologic Antibiotic Resistance in Chinese Elderly People

文献详情

资源类型:
WOS体系:

收录情况: ◇ SCIE

单位: [1]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China
出处:
ISSN:

关键词: Helicobacter pylori antibiotic resistance elderly people molecular pathology eradication treatment

摘要:
Background: The elderly people generally have poor tolerance to drugs and an increased risk of adverse effects. Our study was designed to determine the effect and safety of Helicobacter pylori (H. pylori) eradication treatment based on molecular pathologic antibiotic resistance in Chinese elderly people over the age of 60 years. Methods: A total of 364 people were retrospectively analyzed, including 113 older people over 60 and 251 young and middle-aged people in the age of 20-59 years. Real-time PCR detection and conventional PCR and sequencing method were used for drug susceptibility testing. As the main outcome measure, the eradication rates (ERs) with their 95% confidence intervals (CIs) were analyzed by intention to treat (ITT) and per protocol (PP). For the safety of therapy, adverse events were analyzed. Results: For the total people, the resistance rates to clarithromycin (CLR), amoxicillin (AMX), fluoroquinolone (FLQ) and tetracycline (TET) were 65.06%, 7.54%, 61.39% and 20.37%, respectively. After they were divided into two groups, the resistance rates were 62.39% (CLR), 9.09% (AMX), 69.64% (FLQ) and 22.45% (TET) in the 113 older people over 60, and 66.26%, 6.85%, 57.66% and 19.47% in the 251 young and middle-aged people in 20-59. By the ITT analysis, the ERs were 92.04% (95% CI, 86.97-97.10%, n=113) in the older people and 92.43% (95% CI, 89.14-95.73%, n=251) in the young and middle-aged people. By the PP analysis, the ERs were 96.30% (95% CI, 92.68-99.92%, n=108) and 94.69% (95% CI, 91.87-97.52%, n=245), respectively. No significant differences were shown both in the ITT analysis (P=0.896) and in the PP analysis (P=0.517). The three most common adverse events were black stool, dysgeusia and diarrhea, and no serious adverse event was reported. Conclusion: H. pylori eradication treatment based on molecular pathologic antibiotic resistance showed good effect and safety in Chinese elderly people.

语种:
被引次数:
WOS:
中科院(CAS)分区:
出版当年[2021]版:
大类 | 3 区 医学
小类 | 3 区 传染病学 3 区 药学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 药学 4 区 传染病学
JCR分区:
出版当年[2020]版:
Q2 INFECTIOUS DISEASES Q2 PHARMACOLOGY & PHARMACY
最新[2023]版:
Q2 INFECTIOUS DISEASES Q2 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均[2021-2025] 出版当年[2020版] 出版当年五年平均[2016-2020] 出版前一年[2019版] 出版后一年[2021版]

第一作者:
第一作者单位: [1]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China
通讯作者:
通讯机构: [1]Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China [*1]Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Beijing, 100029, People’s Republic of China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:1320 今日访问量:0 总访问量:817 更新日期:2025-05-01 建议使用谷歌、火狐浏览器 常见问题

版权所有:重庆聚合科技有限公司 渝ICP备12007440号-3 地址:重庆市两江新区泰山大道西段8号坤恩国际商务中心16层(401121)